/* Memory-efficient multiple sequence alignment i/o from Pfam format * * Legacy interface, now that ESL_MSAFILE is rewritten. Still need * to support --small option in various tools, so the necessary parts * of the old interface were moved here. * * To-do: * :: add memory-efficient interface in ESL_MSAFILE * :: add memory-efficient ESL_MSA w/ API * :: add space-efficient MSA file format */ #ifndef eslMSAFILE2_INCLUDED #define eslMSAFILE2_INCLUDED #include #include "easel.h" #include "esl_alphabet.h" /* digital alphabet */ #include "esl_keyhash.h" /* string hashes, for mapping unique seq names */ #include "esl_msa.h" /* ESL_MSA structure */ #include "esl_msafile.h" /* preferred msafile interface, inc. fmt codes shared w/ ESL_MSAFILE2 */ #include "esl_ssi.h" /* indexing large flatfiles on disk */ /* Object: ESL_MSAFILE2 * * Defines an alignment file that we open for reading, * in our legacy version. See ESL_MSAFILE (esl_msafile.c) for the * preferred version. */ typedef struct { FILE *f; /* open file pointer */ char *fname; /* name of file. used for diagnostic output */ int linenumber; /* what line are we on in the file */ char errbuf[eslERRBUFSIZE]; /* buffer for holding parse error info */ char *buf; /* buffer for line input w/ sre_fgets() */ int buflen; /* current allocated length for buf */ int do_gzip; /* TRUE if f is "gzip -dc |" (will pclose(f))*/ int do_stdin; /* TRUE if f is stdin (won't close f) */ int format; /* format of alignment file we're reading */ int do_digital; /* TRUE to digitize seqs directly into ax */ const ESL_ALPHABET *abc; /* digitized input */ ESL_SSI *ssi; /* open SSI index file; or NULL, if none. */ ESL_MSA *msa_cache; /* occasional lookahead at next MSA; GuessAlphabet() */ } ESL_MSAFILE2; /* 1. The ESL_MSAFILE2 object */ extern int esl_msafile2_Open(const char *filename, const char *env, ESL_MSAFILE2 **ret_afp); extern int esl_msafile2_OpenDigital(const ESL_ALPHABET *abc, const char *filename, const char *env, ESL_MSAFILE2 **ret_afp); extern void esl_msafile2_Close(ESL_MSAFILE2 *afp); /* 2. Memory efficient reading/writing in Pfam format */ extern int esl_msafile2_ReadInfoPfam(ESL_MSAFILE2 *afp, FILE *listfp, ESL_ALPHABET *abc, int64_t known_alen, char *known_rf, char *known_ss_cons, ESL_MSA **ret_msa, int *opt_nseq, int64_t *opt_alen, int *opt_ngs, int *opt_maxname, int *opt_maxgf, int *opt_maxgc, int *opt_maxgr, double ***opt_abc_ct, double ***opt_pp_ct, double ****opt_bp_ct, int **opt_spos_ct, int **opt_epos_ct); extern int esl_msafile2_RegurgitatePfam(ESL_MSAFILE2 *afp, FILE *ofp, int maxname, int maxgf, int maxgc, int maxgr, int do_header, int do_trailer, int do_blanks, int do_comments, int do_gf, int do_gs, int do_gc, int do_gr, int do_aseq, ESL_KEYHASH *seqs2regurg, ESL_KEYHASH *seqs2skip, int *useme, int *add2me, int exp_alen, char gapchar2add, int *opt_nseq_read, int *opt_nseq_written); #endif //eslMSAFILE2_INCLUDED