# STOCKHOLM 1.0
#=GF ID   LuxC
#=GF AC   PF05893.5
#=GF DE   Acyl-CoA reductase (LuxC)
#=GF AU   Moxon SJ
#=GF SE   Pfam-B_9766 (release 8.0)
#=GF GA   -133.50 -133.50; 14.60 14.60;
#=GF TC   -133.50 -133.50; 20.40 15.50;
#=GF NC   -133.70 -133.70; 11.20 12.90;
#=GF TP   Family
#=GF BM   hmmbuild -F HMM_ls SEED
#=GF BM   hmmcalibrate --seed 0 HMM_ls
#=GF BM   hmmbuild -f -F HMM_fs SEED
#=GF BM   hmmcalibrate --seed 0 HMM_fs
#=GF AM   globalfirst
#=GF RN   [1]
#=GF RM   9128139
#=GF RT   Cysteine-286 as the site of acylation of the Lux-specific
#=GF RT   fatty acyl-CoA reductase. 
#=GF RA   Lee CY, Meighen EA; 
#=GF RL   Biochim Biophys Acta 1997;1338:215-222.
#=GF DC   The following Pfam-B families contain sequences that according to Prodom
#=GF DC   are members of this Pfam-A family.
#=GF DR   PFAMB; PB029697;
#=GF DR   PFAMB; PB044036;
#=GF DR   PFAMB; PB056333;
#=GF DR   INTERPRO; IPR008670;
#=GF CC   This family consists of several bacterial Acyl-CoA reductase (LuxC)
#=GF CC   proteins. The channelling of fatty acids into the fatty aldehyde substrate
#=GF CC   for the bacterial bioluminescence reaction is catalysed by a fatty acid
#=GF CC   reductase multienzyme complex, which channels fatty acids through the
#=GF CC   thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components [1].
#=GF SQ   13
#=GS Q9KV99_VIBCH/423-818  AC Q9KV99.1
#=GS Q2WLE3_CLOBE/35-425   AC Q2WLE3.1
#=GS Q97GS8_CLOAB/45-446   AC Q97GS8.1
#=GS Q3WCI9_9ACTO/68-470   AC Q3WCI9.1
#=GS LUXC_VIBHA/49-443     AC P08639.1
#=GS Q93CP6_PHOLU/52-446   AC Q93CP6.1
#=GS Q4A539_9VIBR/49-442   AC Q4A539.1
#=GS LUXC_VIBFI/51-445     AC P12748.3
#=GS LUXC2_PHOLE/50-444    AC P29236.1
#=GS Q3KD56_PSEPF/30-413   AC Q3KD56.1
#=GS Q7NQ23_CHRVO/30-413   AC Q7NQ23.1
#=GS Q7MZU4_PHOLL/30-413   AC Q7MZU4.1
#=GS Q8G6W7_BIFLO/65-480   AC Q8G6W7.1
Q9KV99_VIBCH/423-818             LANQPLEAILGLINEARKSWSST............PELDPYRHTGLNF.......LADWCEPNRLKNLLDSALNGQRAFLDNFL..PRKDISHSSQKAMPRGIVSHWLSGNVPLLGMFALVQSILSKNANILKVSASESQALPVLLATFKGLSYTTPGGYTIHGDDLLGTLAVVYF.DRHQTKIAEKFS..ANADVRIAWGGREAIESVSGLPKKYNSQDILFGPKLSMMVVGSDALDSDKAIRKLIRRAATDSSVFDQFACASPHTIFVEKGGLITPKEFAEKLASAMDKALVRLPTQVPDIGQANKIRSKIAE....YAFIGE....YW.HDKHLRWTVLFDEG.........IELVEPTYQRVITVKAVDNVFDVVDSVHED.I...QTVGL.AMNGEKRLRFANEIMLKGAMRCPDVGYMTHFDS..PWDGVVALDRMVRW
Q2WLE3_CLOBE/35-425              IYSYPSEAMIEIINEYSKILCSD............RKFLSYEGVPF.........LVLWLKKDNIKKLLHQDL.KKQEFLDDFI..EIAD..NKFMKAQPRGMVCHFMAGNVPTLPIYYLVQAIICRNVNLCRIPIGSIDIVIELLKPLKDIVINF.RGEKYYGSTLLKSISIINF.SSNDLKLNTEIS..QVADVRVICGGEEAVKTLSVLPKKTTCKDVIFGPKYSFAVFEKSAMESL.KITKTFDNFAKDIISFDQRACSSPQVLFIEKS.TVGINEAAQMLAQALEKSLKRYPKVEINQGAAANIINKRGE....YLISLEK..DII.CSKDLKYTILIDKE.........IILEEPVQHTTIFLKEIEDIFEVCKLITPR....IQTIGIASENNSRIINFANKASLHGVDRLVKVGLMNLYDS..PWDGILFMSEIVKW
Q97GS8_CLOAB/45-446              VHDIKTEETIDLLDRCAKLWLDDNYSKK..HIETLAQITNQSFELVNYEFKS...MMQMLLRENIQNTIKREL.GEVDILDSWH..KTNY...GYEHRQPRGIIFHNISGNAFVVIPMSISMGLLSKNCNLVKVSKDEPYFAYAFYKSLCELDE...........TVKDRLSVLYF.DSSKTEIYDTIV..KNSDGVIHWGGEYSSRIIGEMCAKYQKHMIMHGAKISFEVVDKCD.....DLNKVSEEIAKDIICWEQKACLSPRVVFLN..DKIDVDEFSHCLSASLRKITEVIPKAYLSEWNSVKTIQDRQYCTLKYGMKNERRFKVY.SSFNADYTVILSDGMPEK.....EDINKCF.YRFIFVCPYSSKSDVVNYVSENLKDYLQTMG....YSGNDEEFIEKMTLLGVSIVTKPGKMSLHEPGTSHDGIHNLKEFTFL
Q3WCI9_9ACTO/68-470              LLNVPLKEIIDFLVETGERIRDPRNTFMQDCIDRMAGTHVLPRAVLEGQVKG...AAAYLDKRLLETVVEQNF.PDPRALDEWVPKQDFTGRKSYIRAFAPRLI.HVLPGNSPGVAVKSIAQGALVKAVNLFKMSSSDPFTTVAVLRTMADIDPGH.........PIVRSMSAVYW.RGGDNTVEQVLYRPQYFDKIVAWGGGDAINNVIK.YLGPGFQLVSFDPKTSISMVGREAFASEEALDTAAELAAGDVMVLNQEACVASRFVFVEAD.QAEADRFSERL......HARIVEKAAASGDARPLDADLREQIDVLMMLDDEF..GVW.GKTDGHGLVIRSDE.........PVDFHPI.NKTANVVRVNSLDEAMRYVNVA....TQTVGF.YPFARMADYRDR.LASGGAQRIVRLGEAGPSTIGNPHDAMYPLHRFVHW
LUXC_VIBHA/49-443                LNDLNINNIINFLYTTGQRWKSEEYSRRRAYIRSLITYLGYSPQMAK..LEANWIAMILCSKSALYDIIDTEL.GSTHIQDEWL..PQGE...CYVRAFPKGRTMHLLAGNVPLSGVTSILRGILTRNQCIVRMSASDPFTAHALAMSFIDVDPNH.........PISRSISVLYWPHASDTTLAEELL..SHMDAVVAWGGRDAIDWAVK.HSPSHIDVLKFGPKKSFTVLDHPA.....DLEEAASGVAHDICFYDQNACFSTQNIYFS...GDKYEEFKLKLVEKLNLYQEVLPKSKQSFDDEALFSMTRLE.....CQFSGL..KVI.SEPENNWMIIESEPG........VEYNHPL.SRCVYVHKINKVDDVVQYIEKH.QT..QTISF.YPWESSKKYRDA.FAAKGVERIVESGMNNIFRAGGAHDAMRPLQRLVRF
Q93CP6_PHOLU/52-446              NNKLRLHNIVNFLYTVGQRWKNEEYSRRRTYIRDLKKYMGYSEAMAK..LEANWISMILCSKGGLYDVVENEL.GSRHIMDEWL..PQDE...SYIKAFPKGKSIHLLAGNVPLSVIMSILRAILTKNQCIIKTSSTDPFTANALALSFIDVDPNH.........PITRSLSVVYWPHQGDTSLAKEIM..QHMDVIVAWGGEDAINWAVE.HAPPYADVIKFGSKKSFCIIDNPV.....DLTSAATGAAHDICFYDQRACFSAQNIYYM...GNQYEEFKLALIEKLNLYAHILPNAKKDFDEKAAYSLVQKE.....SLFAGL..KVE.VDVHQRWMIIESNAG........VEFNQPL.GRCVYLHHVDNIEQVLPYVQKN.KT..QTISI.FPWESAFKYRDA.LALRGAERIVEAGMNNIFRVGGSHDGMRPLQRLVTY
Q4A539_9VIBR/49-442              VNNLRLNQVVNFLYTVGQRWRSEEYTRRRTYIRDLTNFLGYSNEMAK..LEANWIAMLLCSKSALYDIVQHDL.GSLHIIDEWI..PQGD...CYIKALPKGKSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSTDPFTATALVSSFIDVNADH.........PITRSMSVMYWSHNEDMSLPKKIM..NHADVV.AWGGDEAIKWAVK.HSPHHVDIVKFGPKKSLSIIDDPE.....DITAAATGVAHDICFYDQQACFSTQNIYYI...GNKLNLFIDELEKKLNVYAKILPKGCQNFDEKAAFTLTEKE.....CLFAGY..QVR.KGENQSWIIIQSPLD........AFGNQPL.SRSVYIHQVSSIEDILPFINKN.TT..QTVSI.APWESSFKYRDE.LAKHGAERIVESGMNNIFRVGGAHDGMRPLQYLVNY
LUXC_VIBFI/51-445                RINLNLNQIVNFLYTVGQRWKSEEYNRRRTYIRELKTYLGYSDEMAR..LEANWIAMLLCSKSALYDIVNYDL.GSIHVLDEWL..PRGD...CYVKAQPKGVSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSSDPFTANALVSSFIDVNADH.........PITKSMSVMYWPHDEDMTLSQRIM..NHADVVIAWGGDEAIKWAVK.YSPPHVDILKFGPKKSLSIIEAPK.....DIEAAAMGVAHDICFYDQQACFSTQDVYYI...GDNLPLFLNELEKQLDRYAKILPKGSNSFDEKAAFTLTEKE.....SLFAGY..EVR.KGDKQAWLIVVSPTN........SFGNQPL.SRSVYVHQVSDIKEIIPFVNKN.RT..QTVSI.YPWEASLKYRDK.LARSGVERIVESGMNNIFRVGGAHDSLSPLQYLVRF
LUXC2_PHOLE/50-444               ENKLTINQIVNFLYTVGQKWKSETYSRRLTYIRDLIKFLGYSQEMAK..LEANWISMILCSKSALYDIVENDL.SSRHIIDEWI..PQGE...CYVKALPKGKSVHLLAGNVPLSGVTSILRAILTKNECIIKTSSADPFTATALVNSFIDVDAEH.........PITRSISVMYWSHSEDLAIPKQIM..SCADVVIAWGGDDAIKWATE.HAPSHADILKFGPKKSISIVDNPT.....DIKAAAIGVAHDICFYDQQACFSTQDIYYI...GDSIDIFFDELAQQLNKYKDILPKGERNFDEKAAFSLTERE.....CLFAKY..KVQ.KGESQSWLLTQSPAG........SFGNQPL.SRSAYIHQVNDISEVIPFVHKA.VT..QTVAI.APWESSFKYRDI.LAEHGAERIIEAGMNNIFRVGGAHDGMRPLQRLVNY
Q3KD56_PSEPF/30-413              ARALDTTTVLGAAAIFAERLQDP............DMAMPIEPEQRQA.......LIGFCQPDALRRKLERELGEQPGSLRRLD..YRQS...RFERWSPLGLVVHITPGNAPLLAFCAVIEGLLAGNVNWLRPSSSDQGLTAQLLHGLAQCDATG.........QIAGHIAVV...PASTAQVGQLC...QRANGVSAWGGESALQAIRQ.QLAPGCRWIDWGHRISFIYLTPAA.....ATPEALDAVADEVCRLDQQACSSPQWLLVDSDDESILRAIGNDLAEAFERRSRHWPVLLPSIQEASEITTRTAMARLAQSFSEVD..GQV..WQAPDWRVIWTHDQ........QLAPSPL.FRSLLLKPLPRA.QVSEQLLPW.RNVLQSAGL.MCAEHETAELAQTLIAAGVTRITPVQAIHDGYEGEPHDGVYALQRLSRR
Q7NQ23_CHRVO/30-413              AAEPDVDAVLSCAERFADALAGA............ERHPLLDEPGRAQ.......LAAFCRREALQAKLERELGERPFSLRRPD..YREP...RFEAWRPLGLVLHVTPSNAALLPFMAALEGLLAGNVNWLRPSSSDQGLSSRLLAELLRHDASG.........RLAARVAVL...PAPSDALPRLM...ADADGVSAWGGDAALSAIRA.RLPAGCRWIDWGHRVSFAYLDPAA.....AADEALDALADDICRFDQQACSSPQALLVDSDDPAAIHEMARRLAAALARRAPLWPALTPDLQEAAEISARMAFHKLDQAFADDQ..GQV..LSGQGWRLAWSMEQ........ELAPSPL.FRTVELRPAPRA.ALARILRPW.RTHLQSCGL.IAPPARLPELSRMLLAAGVSRVAPAGRMHDGYHGEPHDGVYALQRLSRR
Q7MZU4_PHOLL/30-413              ACPPSVQQVLACAERFVDDLDNV............AVKLALDTAALTA.......LRHFCHRDSLEAKLRHELGEQPFSLRRFD..YTQP...RFETWQPLGLVVHITPANAPLLPFMAVLESLLVGNVNWLRPSSSDHGLNAQILAEFLRHDLSG.........TLAPYISVL...PLPSDQLSELL...ACADAVSAWGSNSALTAIRS.QLRPGCRWIDWGHRISFAYFDPMA.....ASDADYDALADDVCRFDQQACSSPQCLLVDSADENVLREVVSAVAAALARRATIWPALQTDIQEAAEISSQMAFLKLDHTFAELR..GSV..EEGNGWRVAWIQRQ........ELAPSPL.YRTLQVRPAPRA.QLVEILLPW.RPYLQSCAL.IVKEKELPMLSRQLLAAGVSRICQAGVMHDGYEGEPHDGVYALTRLARR
Q8G6W7_BIFLO/65-480              LAAMSVNDILDIVADAAQLWADPDFELRRQAELLIPAITGYEPDMVRIELKR...YMRQFRRRELLRFLDSEI.GQPSMLDEFR..PNKA..GGYSKYVGPALTYQVFSSNVPGIPVWSMAMTLLVKGAILGKSSFSEPVMPAFFARSIAMVNSD...........LADAIAVVPW.KGGSQQLEDSAI..DAADAVIVYGSSQTTKLIAG.KVAGSKPCLGYGAKVGLAFIGREALRPD.TYADTVHRVAVDIATYDQQSCLAPQTVFVETDGALTPREVAQLLGGELENQQRKYPRSVLSDAENVAIQRARTDAEMRALMGGKA..AVFASGHSTAWSVLYRELDGSGADEDVASLMSPL.NRTVNVVAVPDLLDAARRLTSC.RGWLQSCGV.AVDSTRLFGLADTLAEVGVNRICPLGEMDRAKSGWHHDGGFNLIDLLRA
#=GC seq_cons                    hsslslppllshlhpsupcWpssp.phh..h...htphhuYspphhp..hct...hhhhCp+suLhcll-p-L.up.chLD-al...pts...sY.+AhP+GlshHlluGNVPLlslhSllculLsKNssllKsSSSDPhhsssLlpohh-lDsst.........slscolSVlYa.cuscspLscplh..spADsVlAWGG--Alchlsp.ptsspschlcFGsKhShull-ssA.....slspAsculAcDIChaDQpAChSsQslalp...ssslcEFspcLuptLs+hscllP+up.shsEpAthotpct-.....shhsth..tVh.pspspsWhllhSptt........thhspPL.pRolhl+tlscl.-llphlpps.ps..QTlul.hshpuphthhsp.LuttGVpRIscsGhhshacsGtsHDGhhsLpRLV+a
//