# STOCKHOLM 1.0
#=GF ID   Patched
#=GF AC   PF02460.9
#=GF DE   Patched family
#=GF AU   Bateman A
#=GF SE   Pfam-B_2400 (release 5.4)
#=GF GA   -436.30 -436.30; 12.00 12.00;
#=GF TC   -435.20 -435.20; 13.60 12.20;
#=GF NC   -436.40 -436.40; 10.70 11.80;
#=GF TP   Family
#=GF BM   hmmbuild -F HMM_ls SEED
#=GF BM   hmmcalibrate --seed 0 HMM_ls
#=GF BM   hmmbuild -f -F HMM_fs SEED
#=GF BM   hmmcalibrate --seed 0 HMM_fs
#=GF AM   globalfirst
#=GF DC   The following Pfam-B families contain sequences that according to Prodom
#=GF DC   are members of this Pfam-A family.
#=GF DR   PFAMB; PB001629;
#=GF DR   PFAMB; PB017440;
#=GF DR   PFAMB; PB019530;
#=GF DR   PFAMB; PB020178;
#=GF DR   PFAMB; PB021972;
#=GF DR   PFAMB; PB024879;
#=GF DR   PFAMB; PB029400;
#=GF DR   PFAMB; PB038755;
#=GF DR   PFAMB; PB050356;
#=GF DR   PFAMB; PB051598;
#=GF DR   PFAMB; PB055718;
#=GF DR   PFAMB; PB080128;
#=GF DR   PFAMB; PB087060;
#=GF DR   PFAMB; PB152475;
#=GF DR   PFAMB; PB170445;
#=GF DR   PFAMB; PB177902;
#=GF DR   PFAMB; PB179724;
#=GF DR   PFAMB; PB182635;
#=GF DR   INTERPRO; IPR003392;
#=GF CC   The transmembrane protein Patched Swiss:P18502 is a receptor
#=GF CC   for the morphogene Sonic Hedgehog. This protein associates with
#=GF CC   the smoothened protein to transduce hedgehog signals.
#=GF SQ   10
#=GS Q09938_CAEEL/52-945  AC Q09938.2
#=GS P91129_CAEEL/47-858  AC P91129.1
#=GS Q19945_CAEEL/49-901  AC Q19945.2
#=GS Q18129_CAEEL/47-926  AC Q18129.1
#=GS O61894_CAEEL/44-830  AC O61894.1
#=GS O16307_CAEEL/1-766   AC O16307.1
#=GS O16530_CAEEL/48-891  AC O16530.2
#=GS Q21883_CAEEL/44-838  AC Q21883.1
#=GS O02246_CAEEL/64-939  AC O02246.2
#=GS O44978_CAEEL/31-791  AC O44978.1
Q09938_CAEEL/52-945             LTLLDARKLYTPVSAP.SWKEEQVFSELWPVKSYEFLPERTFQWNRY..LYLVVHGRPYENGTYPNILEGSYLNDIAKIEEELVTNVSFPREAALEDNPALMRKRHLNETEIEENRN...ITITFKDVCMNW.YGDCYREKNVI................ELLKRRHELNKRGISVTFPQVNQEGTPIYIAFVIGGVDTYP...............................NDTIKYARAMRLWYFLKFDDEEQEQLAKFWEDTAEKFVRETYADH.PTIQCHIKHSRIVDQGLTRNANRLKPYFNVTIAVLVLFTAFYSVKWYFRMDHSWPLHIDWLRSKPMLALGGVLSSVLAILSGIGLLLWFGMFFAEITLIAPFLVL.SIGVDDMFIAVAAWHNTEMKYP..GRSPKV...MKKRMIEAMSESAVAIFITSFTDVLSFGAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALMVISAKAQMSGRNSCMPC.......IT.................AGDIYTIEDGSLQP.....NLKKKKSKSRKDAKAEKEKKDEAKNDKNMEIEENAENAEKSSYDSSPDPSQIHIP..VKSRGAMGHFFRDYYVPWLLNWKTKLFMFVTFIIYLGISVYGICVMEQGLDYDKLLLHSDPLVEALK.REIELFHGGDQIEIAIQNCPNITI.AESRDRIELVAQEFENISYSLGG....KGTSFWMREYKK.Y..S...NLTGSYLNDNRE................SW.IVGVYEWSQLFAFYKL.WSQDFVWA...NESDYDTLELKSYRFRIG..VHRLSTPTDLVLITEELRGVADRHPD..LNIVTYQQSRAIADQLNVILSSTITNDTLAMFCMFCVALIFIPNPICALFITFAMVTIDIGVIGFLSLWSVKLDPISMITIIMSIGFSIEFSAHITHGFVSNDSNL....SAFDRCVDAMEKLAWPVVHGSLSTILGVFVLAFIDSYMVLVFFKTISLVLIIGAWHALMLLPILLSMCIP
P91129_CAEEL/47-858             NPLSDAVYLFTPLGAQ.SKMERMSIHEKWPLTDNNYIPGRAVTQSRE..IQVTALARND.....SNILDPKFANAVYQLDKYIQTRV.......................RVLHNG....HYYSYKNLCLQYKNGGCPSNKHV.................HILSDLHN...HGFNITYPYFRFGSEGGYIGSSLGGVTVMKGEN...........................ETDILASAKAWFMIYHLKFHPEEMSYISGEWELELGRMLTQYPEDP..YISITYFHSQTLADELKRNADTLIPRFIISITLLIVFSTLCSL..SFID...GSFSIDWVLSKPILSILGVVSAGIAILTGVGFLSLMGMPYNDIVGVMPFLVL.AVGVDNMFLMVAAVRRTSRTHT...........VHERMGECLADAAVSILITSSTDVLSFGVGAITTIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEASGRNSLFLI...EAVSAEK..KTSLSTF...........QRLFNLGSVP..................................................DHSASHDVKQ.PLTS.....RFFGEWYAPVLMHPVVRGIAMVWFVIYLLGASYGCSRIKEGLEPVNLLVEDSYAIPHYRLLEKYFWKYGQQVQIVINNAPDLRN.HTSRDRVHAMVLDFATSKHAIGM....ESVQFWLFEMER.YYQ......KELEVQIID.................SS.FYGLLHHFLASKTNNP.LAEDIYWGP..MPDDDNGTMVKSFRFILG..MKDLVTTMDQTDATMSFREVAARWPE..FNVTTFMPIWMFTDQYIIIIPNTVQNIIIALLVMIVIAVLFIPQPMCSLWVALACASIDFGVIGYMTLWGVNLDAISMITIIMSIGFSVDYSAHIAYGYVVSRED.....TAAGRVKEALSALGWPLSQGAMSTIIAVSVLADIPAYMIVTFFKTVVLSISLGLLHGLVFLPVLLSIFVR
Q19945_CAEEL/49-901             LRVDDPSYVFTPSDAR.WRREISVFNENWPLDENKFLPGKSFEAKRFVNILIRAKDGGS.......IMRDNVLHEIEILNQWIMNNI.......................SIPTDD..LKFNLTYQDLCLSY.DWVCGANEHIQML...............LRRNDVN...QILDLHFPRGGTKDTPVYLGGIFGDVQFFQ...............................NGTLSDAKLTQLFYFLKQDQKMVEEYSSKFSYALETFLNQVYSSD..VITLSFAHYQSLEDGLDENAKAFVPNFVVSFFVLAMYALVSSF..TLKS..SSATKIDWISSKPWLAAAGMFSTVLSIISAFGFLFILGVRYNVINTIIPFLII.AIGIDDMFLMNACWDQTSKSLS...........VPERMSKTLSHAGVAVTITNVTDVMSFAIGCITDLPGIQFFCIYACVSVAFSYFYQLTFFSGAMAIMGEVEREKRHCLFFYRTFQLVDISKMNEEADSKL...........QQIKSRSASP.APFNYLSSSNSSFSSDSDSF........SSKKTIPAEFAWKEQQSPNSSLSKKSKDREEKDRIV.....HFIGKIYGPFILSNSVRIFSGLIFVVYLAIAMYGCYNFREGLNPGNLVTNDHYIAKYFSDI.KHFWRIGAQLHVAVLNPPNLTI.SENRNELLKVVSAFENTQYTLGR....EGTVFFLLEYLNYL..S...ELNAEVEDTER.................LW..KTKLNSWLKYTGGSTQWASNLKIN.......KTDGSFQAFRFQIA..LKNFVEPNDHKHAAQLLRDIAD.HQP..FNVVVYHEAFPFADQYLIILPATIQNVVISLLCMAVVSFLLVPSLPSGFVIFVSIVSINIGVFGYMTLWGVNLDAVSMISIIMSIGFAVDLSAHIIYAFVTSHG......DTKQRVIGALETLGWPIFQGASSTIAGISILYTVDAYIILVFFKTIWLTMLIGAIHGLFFIPIFLSLFPV
Q18129_CAEEL/47-926             QTTNDPQYVFSPANAP.WRYERAVLTEHWPLDEEKFWPGKSYDLHGY..VDVIASGRIHPDYGRPNILNIRYLDEVARINDYIIHNL.......................TVPVDINGKHYDIAYTDLCMRY.DWACYLNDHITMLMPKTRWGNFSGPFAELASDIIN...TQVNITYPIGWRGTEPIYFGALVGAPNLVD..............................EEGHFDYASAIRLTYNTR..EGKVDQYGIEWRRKLSMWLTDKENPVSELLEFGVNHNMTLPEGLQDVADTLAPKFVGTCAILFTFSFLVSV..VLRKHRTGQVMPDWVRSKPLVAAAGLMTPIMATVTSFGLILWCGFLYNAIVNVSPFLIL.CIGIDDLFIMCAEWHRTNPQHS...........PEKRIGKTLSEAAVAISITSLTDIATFAMGCYTTLPGVQMFCMYTCVQCFFCYVYQIIFLGPVLAYAAEMEQNGQHVLLIR...KAVDPDK..TESPVKLWLLSGSVNRQDQEARRRNSRKVAPVEKEGEKKSKF......................GEVVEKLEHTLEKHDDDPGHNSEE.TLVS.....KVFREIIGPFILQKSTQVCALLLYLVYISLAIGGCLNIKEGLDPKLLVRESFYLSKFYEIIDETFWREGLQMQVVVNNPPDLFT.PETRKGFDEMMAEFENTQYTMHP....NATMIWLRAYEHHLET......EVHELNIEKPNST............VEW.YTRCRDWLIVAGGRRL.WQMDMVWAN...TTFEETPRITAFRFQLG..LRNYRTPTDHTHSCKLMRSIADKYSM..FNVTTFHEYYPFADQYLELTPSLFQNMISDLCTIFAVSWVMIPELICAVAIVLSIASINVGVLGFMSFWGVNLDSVSIITVIMCIGFSVDLSAHIAYAFSQSYG......NSHARAVAALETLGWPVFLGASSTVLGILLLTLVDSYIVQIFFKTVFLVINFSILHGLIFLPIFLMKVVR
O61894_CAEEL/44-830             IFSFGILNMRTEDDLR.FLYSPEHSLSREEYQVHKDFSGDSKNNSFV..SITIQTSSED.....KNLLKKDLAQKLIQLNKYVLEKM.......................EIQVDG...KIINFGKEVCSRMKQCELSNTIATIFLDT...........FWSEKLRKD...PRIKIEYPTMKFFDNKFFLPTHFYGVQPGG..............................PLGIESIDMVHFVYQIPAYNEHTSEEMSKIFEQSLTALLENQTTFD.....TSMFSLSILKDEMQKNSTYTMPFISLTILLLLCFTVASCM..TDNW..........VTSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTVMPFIAL.AIGVDDVYVMLGAWQDTRRTLD...........AKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREAAGYHCVFVW..............................KRCDREEIAK....................................................AKNENAIS..PTR.....YFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQLVVDDSPLVPYLNLAEKKIWAEGLIGRIYVNNAPDFSKNPEMVDRMLQMVNELESTPYSMGP....NSTNFWLNEFN..NYR......QFFFQEDAK....................FYETLKSFLKVSFNSH.WETDLVWDT.PDKSSKGGTKVEKFVFTTA...FKISNWNIRTSLLLTWRNITSSYPE..FDALVFDENNFYSDQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWVVCTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRIYRSEYS.....DPDERIRDAMGAIGWPVVQAGTSTLLAIVVMLMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSFAT
O16307_CAEEL/1-766              MDNLLRRDYLDGVD...SLAEYLQYNFTVPCS.G..VRGENKLECSF..SDLCSGQCND.........NQKYLNKLRSNNEKNLQ.........................VIPLFN......LIYRNASSRL.....HPN.................................FRLTYPTMHLYNDEYYVGEHFAGVKIDP..............................NTNVISRVKVVVLYFRTDRQTTEVSQVLNNWETSLFDYVENFDHPF...LNMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFIFATNS..REHF.......V..FSHNVVMAILGIAGPLMATGTAFGFLFLFGFPFNSITLVMPFLIIG.VGCDDVFIIIHAMRKTDKSES...........LEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRLMKLQKVGEEK....KIEAAM..ERRPK.............QVLSIQNSIR...................................................STAGAHPPP..ANP.....NGIVSRYCRFLKDWKTRLCLLLVLCGYWTASYYGCKTMEIKMDTTNLIMNDSPLNHIAWIYERFLWSEGQLVMVFVNNPPDLTK.SENLHEVLELVNRFETLPYSMGK....NSTSIWLRSFL..Y........QSSLYHNNK.................GF.NGLLQEWLEDSEGGGA.RWNDMLRLK..KDENGTILGIDKFMFATACAMGDDANWSTREKLQKQWRGVAHEYEH..FNVTVFQSYSFYIDQLDSIGATTMSTVIWAAITMDLACLLMIPGINSILTSTIAMISINIGVFGLLSMWRVNLDPITMCTTLMSIGFSVDFTAHISYHYYRNPTSW....TTDERLADALKSIGWPMIQAASSTVLCIFPLMFNTSYMVWVFVKTILLVTVLGLLHGIIFLPALLLTSGD
O16530_CAEEL/48-891             VLSLKIPFTRMQNDIS.DFTPFGARSRVELEKYRKFFNNHGEPKAIY..AFITSKVGDN.......MLGISQLNDTVHVLDTISRDF.......................YLKTSQ....GPKNFEEYCSGFCLLNEPVKHFYSG...............MLISGQHGTDFSHLDLGYPITTVLGTKLYMDPNFFGVKVTTSNNKVESIADG........NTKLFGDHTKQEPNNIREVSLVVLQFRSELGDEVTPEDLRNYEHQILDYIHDEYQSE..HINVYILTDSYITEEIVRAGLTLLPFLVIGFTIMAVFSSIT......FV..............PILAVMACVCPFMACGASLGAMFFIGFRFGSILCVTPFLVL.AIGVDDSYLMANAWQRITCHRRKHARFESVNVELKNRITEMFIETGPSITITTITNALAFGIGATTPAAEIQLFSIGNALAVITDFVFTITFYGALMAVVGRYEIEQELKTQKP.......LPE..SESP..............SETSSTGSMR......................................................SSELDD..CKF.....RRMIANVCKFLTNTWVCSVVLGLLAVYWYICIVGTVNIKSELSPNKLFLAESNIVEIFKQRKSHIIPYYSACWVLVENPGDINN.PNQRAKLEELIESFEALPSANGR....YSTKFWLRDYEDFLKQSEEIDLPMEEEEDEELAIQFTVNGSQVVTPSQPFGQGNELRQFLEWPEFSF.WKGFIQVN.......ESTYQMSKFLVTTAYHGSDLVDWSNRAKLLNEWRSVADQDKFKSLNVTVYEEDAKFLDLIETMSPVAIQSALWTFASMFLVAALFISHPPTLFVATFSILSTSLGVFGIMSWWGADLDPIMMSATVMSIGFSVDIPSHVSYHFYQTAKDTS...DIRRRLQMTIEAVGFPIFEASLSTSLCVMSLFFVDLNMAQIFAKCMLLVVVIGMVHGMLVMPVIFALLDT
Q21883_CAEEL/44-838             FCSSKICFTKQEDDIKTGYTPVGARSLDEIEVFSDFFASTGDPIAVF..LFITAKDNSS.......MADYNTMKEVVDIMDYVGSN.........................LTHKG......ESFYTLCTDFCQINEPVRQYYNG.............LAMKQQNLSEVG.SRFQLTFPMMQVLGKELDLSPNFFGVKTDE...............................DGNVEYVKIIMLQIRANIPNDWKKEDAAEYERMISQYFHFKYDST..HVTPLAMSLTYTGDEVVRTGLTIFPFIGVGFIIMTTFSIITIY..YSSS.....RLDQWSVHKVSEAILACVCPLLATSSALGTLFWFGFRFGTILCVTPFLIL.AIGVDDAYLQVHACMRLTAEDSSMT........KREKIARMLVEVGPSIAITSMTNLFAFLVGIYTPTPEISLFCAGNAVAILFDFIYQITMYTAILSICENLEMRKN.............AT....K.................RKDSGLSFK.........................................................NEQ....F.....TVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDKLVIGDSPLLQVNYLRDQFVLPNYTTVNIFVQNPGNLTI.QSNLDYMNSLFDSFESYPECLGK....KFSHYFVRDYESFRESS...LEEMEMMEDEEGDTN.........KTALEPFSKAAMSEFLAWPEFQH.WNGFVKFD........KNGMLSKYWATVSYHGEGLGDFQVRRRMLNRWRATADQFAP..LNVSIFDDYAPFVDTLETILPATISTSVCTLICMMIVCFLFMYNVFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACLIMSIGFSVDFPAHITFHYFREGLHDPQS.TPAKRVARSLAAIGFPLLQCGLSTILFVLCLLFVPTYMGEVFVKTMILVVTLGLIHGLFIVPAFLCAFTA
O02246_CAEEL/64-939             LAIVKILLTKQANDIT.GYTPYGARAKDEYLEYQKFFSSSGLPIAAY..LYIVAKDEGS.......MSRPDYLDETIQVLNFALNNI.......................TMYDSIS..GKSETFNQFCQSFCQINEPVRQFYNG.............YQILSDGEQN...SRIKIQYPVSDMFGRQFSLQPNFFGVELFDQPDDAAKLLDSADGDPVIELNATKLVDPVSRITNVKSVKMITLQFRAEHKPGWTEAQVKKWEMSLVDIFEKRYNSK..RLKIYAYSQSYVEEEMVRGGIIMIPYLVVGFAIMCLCSCVLVM..IRAL...Y..MHQENGYKIILAIMACLTPLLACATALALMFLCGVRFASILCVIPFLVL.SIGVDSSYLMIHEWQRVTKHMRETPRKKDS...VGHRMSEVMAEVGPAILISCLTNMFADAVGSFTSSPEITLLCTGNMLSMWFAFIYQMTFYAGLMSIVGGYEFGSDEIDKNR...MEINIAE..NRVN.............IARHHRPLTRQ...................................................PSKFHEATQ..PII.....SDSLQKYTHLMTTPLVFVSVCLVYIAYLAFSVYGITQLNINLTAQKLFALDSPLLELDDLRIKYQVPVYSMATVFVNTPGKLEN.PARLKRLNEFVREMESINGTWGEGWGELGTKYFVRDYDVFQQS......FGSEDEDDEDFMDDDKPVTVHSDDKMTY.REDELKYFLKWPEYDF.WQGFVKLRNATNSTDPEAEELDRFFFTTGYHGDNLTIWTQRGEMLRAWRQVVDKYPD..FGASVFHEDGVYLDLIDNMPTDTWQSILGTLVCMAMVCFVFLNNWFTVAIASLSVLSICAGILGFLSWWKVDLDPITMAAMIISIGFSVDIPAHVSYHYYQASIQEGPMSPPSSRLANCLSSVAFPALQAALSTILCVCSLLFVNLYMAEVFVKTMVLCVVLCNLHGLVFLPAILILLDS
O44978_CAEEL/31-791             VLSSGLVHIRLEPDIRKAFSPDDSDAGYETRVWLEYYGLDIYPERAF..CIFTAKRENS......SILQEGALADIYTVDNRLSAAV.......................GYQDGD......G..RKNCDPLCDLNSPFHLLAN.................LTRRNNG...TTSVFTYPDMPYSGLDIFLGLHLSNADFEP...............................PTERISSKSLVLWYFSRSDTPEGKLAFKDAIDELFQLSKNSSAFE..HVQFTIFSDQVANREMIRGAIEATTLMTIGFFLLLTQVIIVIV..RLSS..........VKMAFYLVATSLLTPMAATVASFGAICWMGFPSFSIQCVTPFLVLG.IGVDDAFILLHRWKHHIAITD...........TPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDYKS.......................................IANET.EP........................................................KISR....A.....DTWLSKYSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNI.KPVFNRYFPITVIVNNPPNIEI.KAEYDSFNNMMDRLEHVPGIRGD....NRSLIFLPQYVNFDKT.....MNILSTLVGEK................YRPSYDNLPTWMDAIGNPP.LVKYHMGD.......DNKTIVTAFRLTLL..GKGMSEWAERARAMQHIRTILHEESQ..FNATLFDCDSAILSIILTVGTDLIGSIAVTVVCMAIVCFVFIANFNAVAVITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRARG......TPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK
#=GC seq_cons                   lssschhahhsssDhp.uhpphsshscp.shs.pcFasucuhststa..lhlsA+spss.......lLc.shLs-lhplscalhssl.......................pl.sss....h.hsacclCpsapphspssppahph................Ltpspps...splslTYPhhphhupplYluspFuGVchhs...............................ssslppsKslhLhapschsscpscphupcaEppLtpalcpphssc..hlphshhosphls-ElpRsuhshhPahslohslLssFohlssh..hhph........p.lppKPlLAlhGlloPlhAslouhGhLFhhGhhFssIlsVhPFLlL.uIGVDDsFlMlsAWc+Tsppps...........sccRhucslsEuGsuIoITSlTslloFulGshTssPuIplFChhsulAlhFsFlYQlTFauAlhulsuchEhpuppshh.h.......hs...pc................pchcspsotp....................................................s.upcspp..hhs.....chhhshYssFltssps+lsslllallYluluhYGssslcpsLsPspLlhsDSsLlchhplh-+alastGptlpVhVNNPPcLsp.spshcclpphlscFEshsaohGc....puTpaWLR-Ycpah.p......php.hcspc.................ta..tspLcpaLchsttsh.Wpsslhhs.....p.csssplspFhFslu..hcslssassRs+hhppaRslADcasp..FNVolFc-sssasDQl.slhssTlpollhsllsMhlVshlFIsshhslhslolullSIslGVhGaLShWGVcLDPIoMlslIMSIGFSVDaoAHIuYpaapuptp.....sspcRltsALpulGWPlhQuuhSTlLslhsLhFVsoYMlhlFsKTllLVlslGhlHGLlhLPllLshhss
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