/* * The MIT License * * Wavefront Alignment Algorithms * Copyright (c) 2017 by Santiago Marco-Sola * * This file is part of Wavefront Alignment Algorithms. * * Permission is hereby granted, free of charge, to any person obtaining a copy * of this software and associated documentation files (the "Software"), to deal * in the Software without restriction, including without limitation the rights * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell * copies of the Software, and to permit persons to whom the Software is * furnished to do so, subject to the following conditions: * * The above copyright notice and this permission notice shall be included in all * copies or substantial portions of the Software. * * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE * SOFTWARE. * * PROJECT: Wavefront Alignment Algorithms * AUTHOR(S): Santiago Marco-Sola * DESCRIPTION: WFA Sample-Code */ #include "utils/commons.h" #include "wavefront/wavefront_align.h" int main(int argc,char* argv[]) { // Patter & Text char* pattern = "TCTTTACTCGCGCGTTGGAGAAATACAATAGT"; char* text = "TCTATACTGCGCGTTTGGAGAAATAAAATAGT"; // Configure alignment attributes wavefront_aligner_attr_t attributes = wavefront_aligner_attr_default; attributes.distance_metric = gap_affine; attributes.affine_penalties.match = 0; attributes.affine_penalties.mismatch = 4; attributes.affine_penalties.gap_opening = 6; attributes.affine_penalties.gap_extension = 2; // Set heuristic wf-adaptive attributes.heuristic.strategy = wf_heuristic_wfadaptive; attributes.heuristic.min_wavefront_length = 10; attributes.heuristic.max_distance_threshold = 50; attributes.heuristic.steps_between_cutoffs = 1; // Initialize Wavefront Aligner wavefront_aligner_t* const wf_aligner = wavefront_aligner_new(&attributes); // Align wavefront_align(wf_aligner,pattern,strlen(pattern),text,strlen(text)); fprintf(stderr,"WFA-Alignment returns score %d\n",wf_aligner->cigar->score); // Count mismatches, deletions, and insertions int i, misms=0, ins=0, del=0; cigar_t* const cigar = wf_aligner->cigar; for (i=cigar->begin_offset;iend_offset;++i) { switch (cigar->operations[i]) { case 'M': break; case 'X': ++misms; break; case 'D': ++del; break; case 'I': ++ins; break; } } fprintf(stderr,"Alignment contains %d mismatches, " "%d insertions, and %d deletions\n",misms,ins,del); // Free wavefront_aligner_delete(wf_aligner); }