/* * The MIT License * * Wavefront Alignment Algorithms * Copyright (c) 2017 by Santiago Marco-Sola * * This file is part of Wavefront Alignment Algorithms. * * Permission is hereby granted, free of charge, to any person obtaining a copy * of this software and associated documentation files (the "Software"), to deal * in the Software without restriction, including without limitation the rights * to use, copy, modify, merge, publish, distribute, sublicense, and/or sell * copies of the Software, and to permit persons to whom the Software is * furnished to do so, subject to the following conditions: * * The above copyright notice and this permission notice shall be included in all * copies or substantial portions of the Software. * * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR * IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, * FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE * AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER * LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, * OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE * SOFTWARE. * * PROJECT: Wavefront Alignment Algorithms * AUTHOR(S): Santiago Marco-Sola * DESCRIPTION: Dynamic-programming alignment algorithm for computing * gap-linear pairwise alignment (Needleman-Wunsch - NW) */ #include "gap_linear/nw.h" /* * NW Traceback */ void nw_traceback( score_matrix_t* const score_matrix, linear_penalties_t* const penalties, cigar_t* const cigar) { // Parameters int** const dp = score_matrix->columns; char* const operations = cigar->operations; cigar->end_offset = cigar->max_operations; int op_sentinel = cigar->end_offset - 1; // Compute traceback int h = score_matrix->num_columns-1; int v = score_matrix->num_rows-1; while (h>0 && v>0) { if (dp[h][v] == dp[h][v-1]+penalties->indel) { operations[op_sentinel--] = 'D'; --v; } else if (dp[h][v] == dp[h-1][v]+penalties->indel) { operations[op_sentinel--] = 'I'; --h; } else { operations[op_sentinel--] = (dp[h][v] == dp[h-1][v-1] + penalties->mismatch) ? 'X' : 'M'; --h; --v; } } while (h>0) {operations[op_sentinel--] = 'I'; --h;} while (v>0) {operations[op_sentinel--] = 'D'; --v;} cigar->begin_offset = op_sentinel + 1; } void nw_align( score_matrix_t* const score_matrix, linear_penalties_t* const penalties, const char* const pattern, const int pattern_length, const char* const text, const int text_length, cigar_t* const cigar) { // Parameters int** dp = score_matrix->columns; int h, v; // Init DP (No ends-free) dp[0][0] = 0; for (v=1;v<=pattern_length;++v) { dp[0][v] = dp[0][v-1] + penalties->indel; } for (h=1;h<=text_length;++h) { dp[h][0] = dp[h-1][0] + penalties->indel; } // Compute DP for (h=1;h<=text_length;++h) { for (v=1;v<=pattern_length;++v) { int min = dp[h-1][v-1] + ((pattern[v-1]==text[h-1]) ? penalties->match : penalties->mismatch); // Misms min = MIN(min,dp[h-1][v]+penalties->indel); // Ins min = MIN(min,dp[h][v-1]+penalties->indel); // Del dp[h][v] = min; } } // Compute traceback nw_traceback(score_matrix,penalties,cigar); }