text:
ation = \Mockery::parseShouldReturnArgs(
            $this, func_get_args(), function ($method) use ($self, $nonPublicMethods, $allowMockingProtectedMethods) {
                $rm = $self->mockery_getMethod($method);
                if ($rm) {
                    if ($rm->isPrivate()) {
                        throw new \InvalidArgumentException("$method() cannot be mocked as it is a private method");
                    }
                    if (!$allowMockingProtectedMethods && $rm->isProtected()) {
                        throw new \InvalidArgumentException("$method() cannot be mocked as it a protected method and mocking protected methods is not allowed for this mock");
                    }
                }

                $director = $self->mockery_getExpectationsFor($method);
                if (!$director) {
                    $director = new \Mockery\ExpectationDirector($method, $self);
                    $self->mockery_setExpectationsFor($method, $director);
                }
                $expectation = new \Mockery\Expectation($self, $method);
                $director->addExpectation($expectation);
                return $expectation;
            }
        );
        return $lastExpectation;
    }

    /**
     * Shortcut method for setting an expectation that a method should not be called.
     *
     * @param mixed
     * @return \Mockery\Expectation
     */
    public function shouldNotReceive()
    {
        $expectation = call_user_func_array(array($this,'shouldReceive'), func_get_args());
        $expectation->never();
        return $expectation;
    }

    /**
     * Allows additional methods to be mocked that do not explicitly exist on mocked class
     * @param String $method name of the method to be mocked
     * @return Mock
     */
    public function shouldAllowMockingMethod($method)
    {
        $this->_mockery_mockableMethods[] = $method;
        return $this;
    }

    /**
     * Set mock to ignore unexpected methods and return Undefined class
     * @param mixed $returnValue the default return value for calls to missing functions on this mock
     * @return Mock
     */
    public function shouldIgnoreMissing($returnValue = null)
    {
        $this->_mockery_ignoreMissing = true;
        $this->_mockery_defaultReturnValue = $returnValue;
        return $this;
    }

    public function asUndefined()
    {
        $this->_mockery_ignoreMissing = true;
        $this->_mockery_defaultReturnValue = new \Mockery\Undefined;
        return $this;
    }

    /**
     * @return Mock
     */
    public function shouldAllowMockingProtectedMethods()
    {
        $this->_mockery_allowMockingProtectedMethods = true;
        return $this;
    }

    /**
     * Set mock to defer unexpected methods to it's parent
     *
     * This is particularly useless for this class, as it doesn't have a parent,
     * but included for completeness
     *
     * @return Mock
     */
    public function shouldDeferMissing()
    {
        $this->_mockery_deferMissing = true;
        return $this;
    }

    /**
     * Create an obviously worded alias to shouldDeferMissing()
     *
     * @return Mock
     */
    public function makePartial()
    {
        return $this->shouldDeferMissing();
    }

    /**
     * Accepts a closure which is executed with an object recorder which proxies
     * to the partial source object. The intent being to record the
     * interactions of a concrete object as a set of expectations on the
     * current mock object. The partial may then be passed to a second process
     * to see if it fulfils the same (or exact same) contract as the original.
     *
     * @param Closure $closure
     */
    public function shouldExpect(\Closure $closure)
    {
        $recorder = new \Mockery\Recorder($this, $this->_mockery_partial);
        $this->_mockery_disableExpectationMatching = true;
        $closure($recorder);
        $this->_mockery_disableExpectationMatching = false;
        return $this;
    }

    /**
     * In the event shouldReceive() accepting one or more methods/returns,
     * this method will switch them from normal expectations to default
     * expectations
     *
     * @return self
     */
    public function byDefault()
    {
        foreach ($this->_mockery_expectations as $director) {
            $exps = $director->getExpectations();
            foreach ($exps as $exp) {
                $exp->byDefault();
            }
        }
        return $this;
    }

    /**
     * Capture calls to this mock
     */
    public function __call($method, array $args)
    {
        return $this->_mockery_handleMethodCall($method, $args);
    }

    public static function __callStatic($method, array $args)
    {
        return self::_mockery_handleStaticMethodCall($method, $args);
    }

    /**
     * Forward calls to this magic method to the __call method
     */
    public function __toString()
    {
        return $this->__call('__toString', array());
    }

    /**public function __set($name, $value)
    {
        $this->_mockery_mockableProperties[$name] = $value;
        return $this;
    }

    public function __get($name)
    {
        if (isset($this->_mockery_mockableProperties[$name])) {
            return $this->_mockery_mockableProperties[$name];
        } elseif(isset($this->{$name})) {
            return $this->{$name};
        }
        throw new \InvalidArgumentException (
            'Property '. __CLASS__. '::'. $name.'does not exist on this mock object'
        );
    }**/

    /**
     * Iterate across all expectation directors and validate each
     *
     * @throws \Mockery\CountValidator\Exception
     * @return void
     */
    public function mockery_verify()
    {
        if ($this->_mockery_verified) {
            return true;
        }
        if (isset($this->_mockery_ignoreVerification)
            && $this->_mockery_ignoreVerification == true) {
            return true;
        }
        $this->_mockery_verified = true;
        foreach ($this->_mockery_expectations as $director) {
            $director->verify();
        }
    }

    /**
     * Tear down tasks for this mock
     *
     * @return void
     */
    public function mockery_teardown()
    {
    }

    /**
     * Fetch the next available allocation order number
     *
     * @return int
     */
    public function mockery_allocateOrder()
    {
        $this->_mockery_allocatedOrder += 1;
        return $this->_mockery_allocatedOrder;
    }

    /**
     * Set ordering for a group
     *
     * @param mixed $group
     * @param int $order
     */
    public function mockery_setGroup($group, $order)
    {
        $this->_mockery_groups[$group] = $order;
    }

    /**
     * Fetch array of ordered groups
     *
     * @return array
     */
    public function mockery_getGroups()
    {
        return $this->_mockery_groups;
    }

    /**
     * Set current ordered number
     *
     * @param int $order
     */
    public function mockery_setCurrentOrder($order)
    {
        $this->_mockery_currentOrder = $order;
        return $this->_mockery_currentOrder;
    }

    /**
     * Get current ordered number
     *
     * @return int
     */
    public function mockery_getCurrentOrder()
    {
        return $this->_mockery_currentOrder;
    }

    /**
     * Validate the current mock's ordering
     *
     * @param string $method
     * @param int $order
     * @throws \Mockery\Exception
     * @return void
     */
    public function mockery_validateOrder($method, $order)
    {
        if ($order < $this->_mockery_currentOrder) {
            $exception = new \Mockery\Exception\InvalidOrderException(
                'Method '. __CLASS__. '::


dataset_name: pile

text:
 he was present for me physically, he was not emotionally. It was just bad luck, jolly bad luck, that I had been present both for my brother’s accident and my mother’s strokes. That my older sister Olivia had been the love of Daddy’s life. That both of us contracted measles, but that she had died.

I think he gave me drugs because he knew no other way to communicate with me to calm me down.

I had seen three different occasions when ambulances came and took away my beloved family never to return them – or to return them as very different people.

These days we know what post-traumatic stress disorder (PTSD) is. I had it. Even now, when I am at home and I hear an ambulance, I am convinced it is coming to my house.

But throughout my teens my parents did not know what to do with me. Dad used to shout: ‘You’re not like normal people.’

I had a career as a model and as a film actress. But, finally, I followed the advice hammered into me and found a rich, successful man to marry me and make me happy.

James Kelly was a kind American, the president of a successful management consultancy. What I did not know is this: no one can make you happy.

After organising a huge wedding and redecorating our mansion in Boston, I sat back waiting to be made happy. Instead I ended up with a Boston psychiatrist who put me on Valium ‘to cry the tears you should have shed in your childhood’.

Things went downhill fast. I became addicted to the Valium, which took away the pain I was feeling about my marriage.

My new husband, in despair, flew me home. I was admitted to hospital under the care of Dr Maurice Lipsedge, Princess Diana’s psychiatrist. This whole foray probably cost £50,000.

Born survivor: Tessa Dahl, pictured in London in 1975, during her modelling days

Tessa Dahl in 1975

My father came to see me and reiterated that I must ‘stop seeing psychiatrists at once. Get on with your marriage’.

So I did as I was told. But it wasn’t a good time. I had two wonderful babies, Clover and Luke, to join Sophie, my other perfect daughter, whom I had with an actor called Julian Holloway before I got married.

I would have huge bouts of energy, buy new houses, have parties, make Christmas shopping lists in July and then be admitted to hospital on intravenous lorazepam [for anxiety] for two weeks.

Just lie in bed crying. Of course, in retrospect, these were the symptoms of bipolar disorder, but no one saw it. Because my finances accommodated it. I was married to a rich man.

After my divorce, I wrote with fervour. All day, often all night. And I bought, decorated and sold houses to make some extra money, too.

I fell in love with a Guru – Gurumayi Chidvilasananda – to whom I donated a lot of money. During those years the yearning was filled with my search for God and meditation. I replaced medication with meditation.

The Guru’s main go-to guy was insidious with his requests. ‘The Guru has chosen you to buy all the ashram children’s party clothes for the birthday celebrations,’ he would say. Or, ‘The Guru has chosen you, as an honour, to buy all her hats for the season.’ You never said no to the Guru.

I was happy and on an amazing search for God. Sadly, this all came tumbling down around me when I began to see the corruption in the world of ‘God in human form’. I was searching to become whole.

And the only things that helped were psycho-pharmaceutical. Drugs. They switched me off from real pain, physical pain, emotional pain, and memories.

Nothing else filled the hole in my heart. Not men, not my wonderful children. Not even the enormous success I was enjoying as a writer.

My journalism was prolific and I published a novel and a string of children’s books. My father could see my writing talent, and said so on television. That was what I was living for.

Then came the worst day of my life. On November 23, 1990, at the age of 74, he died.

Loved by millions: Roald Dahl with a group of children. He was adored the world over by young people for his imaginative stories

After I sold my first children’s book, he had struggled up to his hut with agonised hips to fetch his royalty statements. To prove to me that I would never make as much money as him, however successful I became. More narcissistic than fatherly, perhaps.

But I loved him with an undiluted and unmet passion. He was my major motivation as my whole life consisted of proving to him that, although my sister died, I was still worthy of life and love.

When he died, I felt such a screeching pain, all I knew was I needed to medicate it at once. The pain must be dulled. I telephoned my doctor from Dad’s hospital and within an hour was swallowing oblivion. After my father’s death, my road to doing all I could to numb the pain, day in and day out, consumed me.

My father told me he loved me for the first time the night before he died, which felt cruellest. I had yearned for him to love me for all my life and now he was being taken away.

Selling sweets to movie stars

When we went to Honolulu, Hawaii, with Mummy, she was making a movie called In Harm’s Way. I was seven and hung out with the director, Robert Altman.

For three months, he was the unofficial boss of what we called our Creatures Of The Water Club. He was the blue whale and I was the dolphin. John Wayne’s daughter, the marlin, was in it too. Bob used to leave me little notes written in code in my hotel pigeonhole.

This was before M*A*S*H. Dad had discovered him and they were working on a film script. Dad also had to work on his children’s books in the afternoon – I think Charlie And The Chocolate Factory had just come out – so that meant I could spend time with Bob.

It was a bittersweet time. Mummy had won her Oscar, so she was a huge star. We lived in the first skyscraper hotel in Hawaii. My baby brother and sister, Theo and Ophelia, (and two nannies, excuse me!) were in three adjoining suites, with the balconies covered in mesh.

One day the club, without consulting Bob, decided to open a shop, which involved going to the hotel store, buying lots of sweets and putting them on our parents’ bill.

There was only one problem: we did not have any bags in which to put the sweets before we sold them on.

‘I know,’ I said. ‘I’ve seen bags in the ladies’ loos. They are in each lavatory and very nice. They have a pretty pink rose on them.’

I had solved the problem. The blue whale and I went from room to room, from movie star to movie star in this enormous luxury hotel – Kirk Douglas, Stanley Holloway, John Wayne – selling mints and Smarties. And every time we put our sales in our bags, I would say proudly: ‘Look at these fantastic bags we got in the ladies’ loos. I have no idea what they were doing there.’ I was too young to know that they were sanitary bags.

It was around then that Bob persuaded us to put bubble bath in the fountain. It completely exploded.

And one night a drunken Dad and Bob and I swapped all the shoes left outside the rooms, which was the cause of much grown-up hilarity.

It was always fun to do something with my daddy.

I say it was a bittersweet time because In Harm’s Way was the last film Mum made before her strokes. Although she made a near-miraculous recovery, it was the last time we went on fantastic location trips.

DAVID'S CHARISMA SEDUCED ME INTO FORGETTING EVERYTHING The vacuum in my soul was filled when the great love of my life, the actor David Hemmings, reappeared. His charisma seduced me into forgetting everything. He may have been my great love, but his great love was alcohol. His wife had kicked him out because of his drinking. In the early Nineties I persuaded him to go to an addiction treatment centre in America. He said he would only go if I went. During this time I was drug-free as my only addiction was him. He left me there and went back to his wife, who said if he left me he could drink again. I was so pathetic and heartbroken, I let one of the night counsellors seduce me. Then I confessed all. We were both expelled. I returned to my boyfriend Patrick, who took me back, saying my foray with Hemmings was ‘just a long lunch’.

<|endoftext|>Nevada - Requirements for Solar Power Installation

Nevada State licensing requirements for solar power installers and solar power installations

The rules that regulate the installation of solar power systems are different in each state and even sometimes from county to county. It


text:
 time continue reading. The surprising ending isn’t that surprising, a single line 2/3 through the book just let it slip so that it is clear who is the father.

All in all not a bad book, but I wouldn’t recommend it from the depth of my heart. Still, as Viennese I felt a bit nostalgic with parts of dialect appearing in the book.<|endoftext|>The treatment of colorectal liver metastases with conformal radiation therapy and regional chemotherapy.
Whole-liver radiation, with or without chemotherapy, has been of modest benefit in the treatment of unresectable hepatic metastases from colorectal cancer. A Phase I/II study combining escalating doses of conformally planned radiation therapy (RT) with intraarterial hepatic (IAH) fluorodeoxyuridine (FdUrd) was performed. Twenty-two patients with unresectable hepatic metastases from colorectal cancer, 14 of whom had progressed after previous chemotherapy (2 with prior IAH FdUrd), were treated with concurrent IAH FdUrd (0.2 mg/kg/day) and conformal hepatic radiation therapy (1.5-1.65 Gy/fraction twice a day). The total dose of radiation given to the tumor (48-72.6 Gy) depended on the fraction of normal liver excluded from the high-dose volume. All patients were assessed for response, toxicity, hepatobiliary relapse, and survival. Median potential follow-up was 42 months. Eleven of 22 patients demonstrated an objective response, with the remainder showing stable disease. Actuarial freedom from hepatic progression was 25% at 1 years. The most common acute toxicity was mild to moderate nausea and transient liver function test abnormalities. There were three patients with gastrointestinal bleeding (none requiring surgical intervention) after the completion of treatment. Overall median survival was 20 months. The presence of extrahepatic disease was associated with decreased survival (p < 0.01). Combined conformal radiation therapy and IAH FdUrd can produce an objective response in 50% of patients with hepatic metastases from colorectal cancer. However, response was not durable, and hepatic progression was frequent. Improvements in hepatic tumor control for patients with metastatic colorectal cancer may require higher doses of conformal radiation and/or improved radiosensitization. In an effort to increase radiosensitization, we have recently initiated a clinical trial combining IAH bromode-oxyuridine, a thymidine analog radiosensitizer, with conformal high dose radiation therapy.<|endoftext|>Spousal negative responses to cancer patients: the role of social restriction, spouse mood, and relationship satisfaction.
This cross-sectional study examined perceptions of spousal negative behaviors in 219 cancer patients. A mediational model was proposed to explain why a spouse might respond negatively to an ill partner because of greater restriction on activities as functional impairment increases. A moderating effect of the spouse's marital satisfaction assessed 3 months before other study measures was also proposed. Results provided support for the proposed model. The relationship between increasing patient functional impairment and spousal negative behaviors was medicated by greater restriction in spouse activities, as well as spousal negative mood. A marginally significant moderating effect for marital satisfaction was found. Although these results must be replicated with a prospective study, the findings begin to shed light on why spouses might respond in negative ways to an ill partner.<|endoftext|>Othippiini

Othippiini is a tribe of true weevils in the beetle family Curculionidae. Of the eight genera in Othippiini, only Egiona and Othippia are not monotypic. Acoptus suturalis is the only species of the tribe found in the New World.

Genera
These eight genera belong to the tribe Othippiini:
 Abrimoides Kojima & Lyal, 2002
 Acoptus LeConte, 1876
 Brimoda Pascoe, 1871
 Brimoides Kojima & Lyal, 2002
 Chelothippia Marshall, 1938
 Egiona Pascoe, 1874
 Othippia Pascoe, 1874
 Rimboda Heller, 1925

References

Further reading

Category:Weevils<|endoftext|>The present invention concerns methods of making triple decker sandwich coordination compounds and intermediates useful for carrying out such methods.
The storage of information at the molecular level can afford extraordinarily high memory densities. An approach toward molecular-based information storage that involves the storage of data in distinct molecular oxidation states has been developed. (see, e.g., Lindsey, U.S. Pat. No. 6,212,093; Roth, et al. (2000) J. Vac. Sci. Technol. B 18:2359-2364; Gryko, et al. (2000) J. Org Chem. 65:7345-7355; Gryko, et al. (2000) J. Org. Chem. 65:7356-7362; Clausen, et al. (2000) J. Org. Chem. 65:7363-7370; Clausen, et al. (2000) J. Org Chem. 65:7371-7378; Li, et al. (2000) J. Org. Chem. 65:7379-7390; Gryko, et al. (2001) J. Mater. Chem. 11: 1162-1180). Thiol-derivatized redox-active molecules are attached to an electroactive surface, thereby enabling reading and writing to be achieved via electrical methods (Roth, et al. Anal. Chem. submitted). The information storage density can be increased commensurate with the number of available oxidation states of the molecules in a memory storage location.
Among the various classes of molecules examined for information storage, (Gryko, et al. (2000) J. Org. Chem. 65:7345-7355; Gryko, et al. (2000) J. Org. Chem. 65:7356-7362; Clausen, et al. (2000) J. Org. Chem. 65:7363-7370; Clausen, et al. (2000) J. Org. Chem. 65:7371-7378) the triple-decker lanthanide sandwich molecules (Tran-Thi, T. -H. (1997) Coord. Chem. Rev. 160:53-91; Ng and Jiang (1997) Chem. Soc. Rev. 26:433-442) comprised of porphyrinic ligands proved most attractive due to their large number of redox states, reversible electrochemistry, and relatively low oxidation potentials. The triple deckers generally exhibit four oxidation states in the range 0-1.4 V (vs Ag/Ag+), corresponding to the formation of the monocation, dication, trication, and tetracation (Li, et al. (2000) J. Org. Chem. 65:7379-7390; Gryko, et al. (2001) J. Mater. Chem. 11: 1162-1180). A further attraction of this class of molecules stems from the possibility of interleaving the potentials of two triple deckers, thereby achieving as many as eight accessible cationic oxidation states. This approach for molecular-information storage requires the ability to synthesize triple deckers of a given type bearing linkers for attachment to an electroactive surface.
The synthesis of homoleptic porphyrin triple deckers, first reported by the groups of Buchler (Buchler and Knoff (1985) In: Optical Properties and Structure of Tetrapyrroles; Blauer, G.; Sund, H., Eds.; de Gruyter: Berlin, pp 91-105) and Weiss (Buchler, et al. (1986) J. Am. Chem. Soc. 108:3652-3659), employed the reaction of a lanthanide acetylacetonate complex with a porphyrin in refluxing 1,2,4-trichlorobenzene (1,2,4-trichlorobenzene has bp 214xc2x0 C.; the oil bath temperature for these reactions was set at xcx9c230xc2x0 C.). This procedure grew out of a method developed by Horrocks for the preparation of (Por)M(acac) complexes by reaction of a porphyrin with a lanthanide(acac) complex in refluxing 1,2,4-trichlorobenzene (Wong, et al. (1974) J. Am. Chem. Soc. 96:7149-7150; Wong, C. -P. (1983) Inorg. Synth. 22:156-162). The synthesis of heteroleptic (porphyrin/phthalocyanine) triple deckers has been achieved by two distinct procedures, an undirected xe2x80x9creaction-of-monomersxe2x80x9d route and a directed xe2x80x9cmonomer+dimerxe2x80x9d route (vide infra). The former route proceeds as follows: A porphyrin is treated with excess M(acac)3.nH2O in refluxing 1,2,4-trichlorobenzene, affording the porphyrin.M(acac) complex (Moussavi, et al. (1986) Inorg. Chem. 25:2107-2108). The mixture is then treated with a dilithium phthalocyanine under continued reflux. In various applications of this method it has become clear that the product composition depends on the lanthanide, the nature of the substituents on the porphyrin and phthalocyanine, and the ratio of the reactants (Ng and Jiang (1997) Chem. Soc. Rev. 26:433-442


text:
ner.de:443/',
  'http://tvdate.ru:443/',
  'http://www.epublibre.org:443/',
  'http://www.zenefits.com:443/',
  'http://themoneyconverter.com:443/',
  'http://pantheon.io:443/',
  'http://fabric.com:443/',
  'http://www.seroundtable.com:443/',
  'http://www.value-domain.com:443/',
  'http://www.searchsafe.co:443/',
  'http://hitwe.com:443/',
  'http://www.americanexpress.com:443/',
  'http://smittenkitchen.com:443/',
  'http://www.mozilla.org:443/',
  'http://mr-jatt.com:443/',
  'http://www.sony.ru:443/',
  'http://www.bankofthewest.com:443/',
  'http://www.lucidchart.com:443/',
  'http://www.ondvdreleases.com:443/',
  'http://www.sony.co.uk:443/',
  'http://carousell.com:443/',
  'http://www.nist.gov:443/',
  'http://www.quickteller.com:443/',
  'http://www.meinbezirk.at:443/',
  'http://poloniex.com:443/',
  'http://percentagecalculator.net:443/',
  'http://www.searchincognito.com:443/',
  'http://www.sophos.com:443/',
  'http://casper.com:443/',
  'http://www.bitfinex.com:443/',
  'http://www.diki.pl:443/',
  'http://52poke.com:443/',
  'http://www.randyblue.com:443/',
  'http://qiwi.com:443/',
  'http://www.stitchfix.com:443/',
  'http://codecanyon.net:443/',
  'http://www.trekbikes.com:443/',
  'http://servis24.cz:443/',
  'http://www.giustizia.it:443/',
  'http://www.varsitytutors.com:443/',
  'http://www.newegg.com:443/',
  'http://atom.io:443/',
  'http://bitpay.com:443/',
  'http://www.xing.com:443/',
  'http://www.desidime.com:443/',
  'http://tinypng.com:443/',
  'http://www.rehlat.com:443/',
  'http://vip.wordpress.com:443/',
  'http://www.metropcs.com:443/',
  'http://www.mygov.in:443/',
  'http://www.marlboro.com:443/',
  'http://cakes.mu:443/',
  'http://www.semrush.com:443/',
  'http://waplog.com:443/',
  'http://mapy.cz:443/',
  'http://stripchat.com:443/',
  'http://nearpod.com:443/',
  'http://buffer.com:443/',
  'http://www.duedil.com:443/',
  'http://www.cartrade.com:443/',
  'http://att.yahoo.com:443/',
  'http://www.netatmo.com:443/',
  'http://www.cd.cz:443/',
  'http://hide.me:443/',
  'http://ascii2d.net:443/',
  'http://www.hackerrank.com:443/',
  'http://convertio.co:443/',
  'http://www.skoob.com.br:443/',
  'http://www.thetechgame.com:443/',
  'http://www.numbeo.com:443/',
  'http://www.blablacar.ru:443/',
  'http://modhoster.de:443/',
  'http://pivotaltracker.com:443/',
  'http://www.freecycle.org:443/',
  'http://picclick.co.uk:443/',
  'http://shopgoodwill.com:443/',
  'http://www.bilyoner.com:443/',
  'http://riffstation.com:443/',
  'http://uspto.gov:443/',
  'http://gisher.org:443/',
  'http://www.gearbubble.com:443/',
  'http://www.ccavenue.com:443/',
  'http://www.hathitrust.org:443/',
  'http://unsee.cc:443/',
  'http://www.grailed.com:443/',
  'http://piratebay.red:443/',
  'http://heteml.jp:443/',
  'http://womany.net:443/',
  'http://www.azadliq.info:443/',
  'http://f5.com:443/',
  'http://zoho.com:443/',
  'http://dubizzle.com:443/',
  'http://www.unibet.com:443/',
  'http://aglasem.com:443/',
  'http://topwar.ru:443/',
  'http://www.lowyat.net:443/',
  'http://www.zarinpal.com:443/',
  'http://imp.free.fr:443/',
  'http://avxhome.se:443/',
  'http://advego.ru:443/',
  'http://au.ru:443/',
  'http://www.dubtrack.fm:443/',
  'http://www.23andme.com:443/',
  'http://www.eobuwie.com.pl:443/',
  'http://ficbook.net:443/',
  'http://payeer.com:443/',
  'http://yadi.sk:443/',
  'http://pingidentity.com:443/',
  'http://www.pearsonrealize.com:443/',
  'http://www.propublica.org:443/',
  'http://www.kaskus.co.id:443/',
  'http://tarot.com:443/',
  'http://gaijinpot.com:443/',
  'http://www.freenet.de:443/',
  'http://www.carthrottle.com:443/',
  'http://www.casinohuone.com:443/',
  'http://www.drugabuse.gov:443/',
  'http://xakep.ru:443/',
  'http://www.pfsense.org:443/',
  'http://pes-patch.com:443/',
  'http://www.qwertee.com:443/',
  'http://webmail.bell.net:443/',
  'http://www.costco.com:443/',
  'http://www.expressvpn.com:443/',
  'http://www.kuantokusta.pt:443/',
  'http://www.sec.gov:443/',
  'http://theconstructor.org:443/',
  'http://uclouvain.be:443/',
  'http://www.budget.com:443/',
  'http://www.one.com:443/',
  'http://cine.to:443/',
  'http://www.webnode.com.br:443/',
  'http://mbank.pl:443/',
  'http://www.moe-acg.us:443/',
  'http://sportsmansoutdoorsuperstore.com:443/',
  'http://www.helpshift.com:443/',
  'http://www.travelodge.co.uk:


text:
 need to have blood drawn to test for HIV. (Id. at 72.) Wengert then said to Rozak, "nobody was aware of this, but I am HIV positive, so you're going to find out that I have it." (Id.) Rozak told Wengert that Marian Oglesby, Wyncote's director of nursing prior to Schlener, had informed her that Wengert was possibly HIV-positive. (Id. at 72-73; see also Pl.'s Resp. Ex. D [Def.'s Resps. to Pl.'s First Set of Admis.] at 3.)

Wengert believed that a number of his co-workers were aware of his HIV-positive status. According to Wengert, he would from time to time arrive at work with notes from the Jonathan Lax Treatment Center, which treats patients with HIV. (Wengert Dep. at 74-75.) Wengert suggested that employees at Wyncote could have learned of his HIV-positive status based on these notes. (Id.) He also contended that Alessandro's behavior toward Wengert changed after the biting incident, thereby suggesting that she knew that he was HIV-positive. (Id. at 80.) Based on an incident when Moore disciplined Wengert for failing to use gloves when he took a resident to the bathroom, Wengert also...

Our website includes the first part of the main text of the court's opinion.
To read the entire case, you must purchase the decision for download. With purchase,
you also receive any available docket numbers, case citations or footnotes, dissents
and concurrences that accompany the decision.
Docket numbers and/or citations allow you to research a case further or to use a case in a
legal proceeding. Footnotes (if any) include details of the court's decision. If the document contains a simple affirmation or denial without discussion,
there may not be additional text.

Buy This Entire Record For
$7.95

Download the entire decision to receive the complete text, official citation,
docket number, dissents and concurrences, and footnotes for this case.<|endoftext|>Caregiving by country

Caregiving by country is the regional variation of caregiving practices as distinguished among countries.

Caregivers Internationally

Australia
According to the Australian Bureau of Statistics 2001 paper on the health and well being of Carers, Carers save the Australian Federal Government over $30 billion a year, according to the same statistics there are over 300 000 Young Carers (Carers Australia states that a Young carer is any carer under the age of 25) with 1.5 million potential young carers, where potential is defined as a young person who lives in a household where there is at least one person who requires full-time care (Is disabled etc.). In 2015, carers provided around 1.9 billion hours of unpaid care. According to a new study by the University of Queensland, Australian carers are providing $13.2 billion worth of free mental health support to their friends and family members. This "hidden workforce" is an equivalent of 173,000 full-time mental health support workers.

In Australia they also have The Australian National Young Carers Action Team (ANYCAT) whose goal is to advocate on behalf of young carers (Being young carers themselves) each board member is the sole representative of their state or territory and represent as few as 75 000 Young Carers.
In Most states and Territories they have an ANYCAT equivalent team or Board. In Queensland this is called Young Carers Action Board Queensland (YCABQ).

China
According to the National Bureau of Statistics of China 2011 report regarding China’s total population and structural changes, people belong to the age group of 60 years and above accounted for 184.99 million, which occupied 13.7 percent of the total national population at the end of 2011. The number has risen 0.47 percentage point comparing to the year of 2010. Of these, people age 65 years and above figured up 122.88 million that occupied 9.1 percent of the total and has increased 0.25 percentage points.

As a steadily increasing older population with a growing demand for long-term care, an issue of lacking of elderly care facilities as well as inadequate training for skilled caregivers has generated a social concern pertaining to elder care. According to the official Chinese media Xinhua, professionally qualified caregivers are in great request with approximately 10 million people needed to provide care for the Chinese aging population. However, the report also stated that only 300,000 people currently working as caregivers with less than 1/3 of them are trained properly.

There is no organized caregiver association in China. As a result, family members still construct the major source of caregiving in China especially in rural area where the quality of health services is a problem. A recent study aims to examine the effect of depression on family members of whom sons and daughters-in-law carry out main responsibilities in caring for elderly parents have indicated several findings, including:

 The majority of caregivers choose to rely on medical resources (physicians and traditional healers) during the caregiving for older people.
 The depression score varied significantly between caregivers of healthy and non-healthy older adults.
 The severity of depressive expression associated with background of caregiving, like caregiver’s income, age, and the time spent on caregiving.
 Social support plays an important role in impacting the status of depression among family caregivers.

More recently, another Caregiver Reaction Assessment was conducted in China with a purpose to analyze the reliability and validity among family caregivers of cancer patients. The study recruited 400 participants from the Second Affiliated Hospital of China Medical University in Shenyang with 312 family caregivers completed the survey. This study tried to measure caregiving experience from five aspects: disrupted schedule, financial problems, lack of family support, health problems, and self-esteem. The results indicated that the Chinese version of caregiving is profoundly influenced by the conception of Confucianism that emphasizes filial piety and guides the traditional caregiving ideology. Furthermore, the average age of adult children provide care is 46 years old of whom the majorities still work to support the family. As such, adult children sometimes bear significant physical and mental strain when their personal schedule and life activities are negatively impacted.

Israel
In Israel, one of the most significant challenges regarding caring is coping with the increasing number of dementia patients. The illness is Israel's second leading cause of disability among the elderly aged 70+ and is considered one of the most distressing and difficult conditions for the patients and their families.  Due to its extensive implications, dementia is a challenge for the health and social service systems and its economic impact on society is considerable.  In 2013, Israel adopted a National Strategic Plan to Address Alzheimer's and Other Types of Dementia, which emphasized the need to relate specifically to the needs of family caregivers of elderly dementia patients – in other words to treat them as a target population of the service system in their own right.

Italy
When compared to all other countries Italy has the highest percentage of residents who are age 65 and older.  The life expectancy for males is 76.7 and 82.9 for females, and it is predicted that by 2050 these numbers will reach 81 and 86 years, for men and women respectively. In addition, the country is faced with a rapidly growing older population and a shortage of younger individuals. Furthermore, the Minister of Labor and Social Policies of Italy stated that the family plays the most important role in the quality of life of elders, and it is the primary care provider for the older populations; however, the government also provides assistance to the family care giver by the following services:
"Qualified assistance at home"
 "Support services"
 "Service vouchers"
 "Daytime centres to provide support for families by offering old people rehabilitation and recreation"
 "Stays in holiday resorts for non self-sufficient old people - including those staying in hospitals or homes"
The family plays an important role in providing care to its older parents but many children still have to work so that they can survive financially and as a result many caregivers are immigrant workers. These immigrant workers come in search of work from many parts of the world such as Moldavia, the Philippines, and Peru; however, the largest population of immigrant workers come from Ukraine. Many of the caregivers work long hours and weeks, and also leave their own families behind and send them the money they make.

Taiwan
Taiwan Today reports that currently in Taiwan only 72,000 seniors, about one third of those receiving long-term care, live in nursing institutes. The rest are taken care of by family members. Chen indicates that there were 600,000 family caregivers in Taiwan and they spent an average of 13.55 hours a day caregiving. 80 percent of these 600,000 family caregivers encountered limitations on social activities. 70 percent of them needed to take care of patients even when they did not feel well. He also mentions that 80 percent of family caregivers are women, and 50 percent of them are over 50 years old. Women are more likely to be regarded as natural caregivers because of gender expectations. Taiwanese females take care of children and spouses with chronicle illnesses to meet social norms and maintain filial piety. Among the family caregivers in Taiwan, some of them suffer from guilt, depression, nervousness, and injuries, sleeplessness, and hopelessness. Thus, it is a very essential task to promote the capabilities of family caregivers and improve their life quality.

Ukraine
The average life expectancy in Ukraine is 61 for men and 72 for women, and as of 2005 Ukraine’s population is about 48 million of whom 15% are 65 and older. Older adults who cannot take care of themselves rely on family members, humanitarian organizations, government


text:
# FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR
# OTHER DEALINGS IN THE SOFTWARE.

"""
Strip accents and splits linked letters from the full set of Unicode
Latin characters for ASCII compatability.

Usage:
import accentStrip
noAccents = accentStrip.auto_convert(u'some string with accents') automatically choose best method
noAccents = accentStrip.full_convert(u'some string with accents') full conversion, slow for large strings
noAccents = accentStrip.fast_convert(u'some string with accents') no squashing but much faster for large strings

Input is Unicode, the output is Unicode which will map directly to ASCII.
Up to you to convert to/from your encoding.
"""

from __future__ import print_function

# dictionary used to convert characters
lookup = {
    # uppercase
    u'À' : u'A',
    u'�?' : u'A',
    u'Â' : u'A',
    u'Ã' : u'A',
    u'Ä' : u'A',
    u'Å' : u'A',
    u'Ā' : u'A',
    u'Ă' : u'A',
    u'Ą' : u'A',
    u'Ḁ' : u'A',
    u'Ạ' : u'A',
    u'Ả' : u'A',
    u'Ấ' : u'A',
    u'Ầ' : u'A',
    u'Ẫ' : u'A',
    u'Ậ' : u'A',
    u'Ắ' : u'A',
    u'Ằ' : u'A',
    u'Ẳ' : u'A',
    u'Ẵ' : u'A',
    u'Ặ' : u'A',
    u'Ḃ' : u'B',
    u'Ḅ' : u'B',
    u'Ḇ' : u'B',
    u'Ƀ' : u'B',
    u'Ç' : u'C',
    u'Ć' : u'C',
    u'Ĉ' : u'C',
    u'Ċ' : u'C',
    u'Č' : u'C',
    u'Ḉ' : u'C',
    u'Ď' : u'D',
    u'�?' : u'D',
    u'Ḋ' : u'D',
    u'Ḍ' : u'D',
    u'Ḏ' : u'D',
    u'�?' : u'D',
    u'Ḓ' : u'D',
    u'È' : u'E',
    u'É' : u'E',
    u'Ê' : u'E',
    u'Ë' : u'E',
    u'Ē' : u'E',
    u'Ĕ' : u'E',
    u'Ė' : u'E',
    u'Ę' : u'E',
    u'Ě' : u'E',
    u'Ḕ' : u'E',
    u'Ḗ' : u'E',
    u'Ḙ' : u'E',
    u'Ḛ' : u'E',
    u'Ḝ' : u'E',
    u'Ẹ' : u'E',
    u'Ẻ' : u'E',
    u'Ẽ' : u'E',
    u'Ế' : u'E',
    u'Ề' : u'E',
    u'Ể' : u'E',
    u'Ễ' : u'E',
    u'Ệ' : u'E',
    u'Ɇ' : u'E',
    u'Ḟ' : u'F',
    u'Ĝ' : u'G',
    u'Ğ' : u'G',
    u'Ġ' : u'G',
    u'Ģ' : u'G',
    u'Ḡ' : u'G',
    u'Ĥ' : u'H',
    u'Ħ' : u'H',
    u'Ḣ' : u'H',
    u'Ḥ' : u'H',
    u'Ḧ' : u'H',
    u'Ḩ' : u'H',
    u'Ḫ' : u'H',
    u'Ⱨ' : u'H',
    u'Ì' : u'I',
    u'�?' : u'I',
    u'Î' : u'I',
    u'�?' : u'I',
    u'Ĩ' : u'I',
    u'Ī' : u'I',
    u'Ĭ' : u'I',
    u'Į' : u'I',
    u'İ' : u'I',
    u'Ḭ' : u'I',
    u'Ḯ' : u'I',
    u'Ỉ' : u'I',
    u'Ị' : u'I',
    u'Ĵ' : u'J',
    u'Ɉ' : u'J',
    u'Ķ' : u'K',
    u'Ḱ' : u'K',
    u'Ḳ' : u'K',
    u'Ḵ' : u'K',
    u'Ⱪ' : u'K',
    u'Ĺ' : u'L',
    u'Ļ' : u'L',
    u'Ľ' : u'L',
    u'Ŀ' : u'L',
    u'�?' : u'L',
    u'Ḷ' : u'L',
    u'Ḹ' : u'L',
    u'Ḻ' : u'L',
    u'Ḽ' : u'L',
    u'Ⱡ' : u'L',
    u'Ɫ' : u'L',
    u'Ḿ' : u'M',
    u'Ṁ' : u'M',
    u'Ṃ' : u'M',
    u'Ñ' : u'N',
    u'Ń' : u'N',
    u'Ņ' : u'N',
    u'Ň' : u'N',
    u'Ŋ' : u'N',
    u'Ṅ' : u'N',
    u'Ṇ' : u'N',
    u'Ṉ' : u'N',
    u'Ṋ' : u'N',
    u'Ò' : u'O',
    u'Ó' : u'O',
    u'Ô' : u'O',
    u'Õ' : u'O',
    u'Ö' : u'O',
    u'Ø' : u'O',
    u'Ō' : u'O',
    u'Ŏ' : u'O',
    u'�?' : u'O',
    u'Ṍ' : u'O',
    u'Ṏ' : u'O',
    u'�?' : u'O',
    u'Ṓ' : u'O',
    u'Ọ' : u'O',
    u'Ỏ' : u'O',
    u'�?' : u'O',
    u'Ồ' : u'O',
    u'Ổ' : u'O',
    u'Ỗ' : u'O',
    u'Ộ' : u'O',
    u'Ớ' : u'O',
    u'Ờ' : u'O',
    u'Ở' : u'O',
    u'Ỡ' : u'O',
    u'Ợ' : u'O',
    u'Ṕ' : u'P',
    u'Ṗ' : u'P',
    u'Ɋ' : u'Q',
    u'Ŕ' : u'R',
    u'Ŗ' : u'R',
    u'Ř' : u'R',
    u'Ṙ' : u'R',
    u'Ṛ' : u'R',
    u'Ṝ' : u'R',
    u'Ṟ' : u'R',
    u'Ɽ' : u'R',
    u'Ɍ' : u'R',


text:
uous material, with densities of $10^3$[cm$^{-3}$]{} or lower.

We model the emission from a $0.4$ pc box centred on the collapsing core. The original SPH simulation is interpolated to a grid with a cell size of $2{\times 10}^{-3}$ pc. For a core at a distance of 150 pc this corresponds to a resolution of around 2.8 arcseconds. However, the line profiles are measured over a Gaussian beam with a full width half maximum (FWHM) of 0.01pc, which corresponds to 13.7 arcseconds. The models are selected at a time period where the central core has just started collapsing and a sink particle is about to form in the simulation. In observational parlance the cores could be considered as starless objects that are about to begin their ‘Class 0’ phase of core evolution.

In order to make a comparison to observational data we estimate the mass of the filaments by calculating the total mass of gas in our grid models with a density in the range $5{\times 10}^3$[cm$^{-3}$]{} $< n < 3 {\times 10}^4$[cm$^{-3}$]{}. For Filaments A, B and C we obtain values of 6.4 [M$_{\odot}$ ]{}, 12.3 [M$_{\odot}$ ]{}and 14.7 [M$_{\odot}$ ]{}respectively. @Hacar11 find values in the range 4.8 [M$_{\odot}$ ]{}to 11.3 [M$_{\odot}$ ]{}for four filaments they studied in L1517. Our values are therefore in good agreement with the masses of observed filaments.

Furthermore, we also find good agreement when comparing our simulation to observed column densities in star-forming regions. The bottom panel of [Figure ]{}\[dg\_image\] shows a column density projection from the original simulation of each filament before radiative transfer, which has been smoothed as if observed by a 0.01pc width Gaussian beam. The column densities of our filaments are in the range $10^{22} -10^{23}$ [cm$^{-2}$]{} with a typical column density of around $4{\times 10}^{22}$ [cm$^{-2}$]{}, and an increase in column density at the location of the dense embedded cores. @Menshchikov10 find column densities in the range $5{\times 10}^{20}-1.4{\times 10}^{23}$ [cm$^{-2}$]{} for filaments in Aquila, and column densities of $3{\times 10}^{20}-8.6{\times 10}^{21}$ [cm$^{-2}$]{} for filaments in Polaris. Our filaments resemble dense filaments in Aquila far more than the Polaris filaments. This is reasonable as they are extracted from a simulation undergoing rapid star formation like that seen in the Aquila field. The Polaris region contains no clear examples of pre-stellar cores [@Ward-Thompson10]. In conclusion our model filaments closest observational analogue is to dense star-forming filaments in clustered regions rather than diffuse quiescent filaments.

Molecular line modeling
-----------------------

We use the radiative transfer code RADMC-3D [^1] to carry out the line modelling of the cores. RADMC-3D models a variety of radiative processes including dust thermal emission and absorption, dust scattering, as well as gas atomic and molecular lines. It is this latter capability which is of importance here.

The chemical species which we will consider in this paper have emission lines with high critical densities and as such are typically not in local thermal equilibrium (LTE). Consequently, a non-LTE approach must be used for the line transfer. We use the large velocity gradient (LVG) approximation [@Sobolev57] which uses local velocity gradients to define photon escape probabilities. For a full description of how LVG has been implemented in RADMC-3D see @Shetty11 [a]. We also use a method known as ‘Doppler catching’ to interpolate under-resolved velocities along each line of sight as described in @Shetty11b [b]

In the cores studied here a given line of sight velocity may occur at more than one position and so the assumption of LVG is not fully satisfied. However, @Ossenkopf97 showed that the Sobolev approximation can be used in regimes where it does not strictly apply, such as turbulent flows in molecular clouds, and still yield reasonably accurate results. In spherical homogeneous flows like the idealised case shown in [Figure ]{}\[theory\], he found that the error had a maximum value of only $20\%$. Moreover this error was mainly in the line intensity, rather than in the shape of the line profile. We test this further by calculating the LTE line profiles for our cores and then comparing them to the LVG results. In LTE the maximum intensities are higher due to the artificially high level populations. However, both methods show a dip at the same velocity in the line profile, and so we can be confident that our assumption of LVG is not affecting the qualitative behaviour of the lines. We also tested our method using a completely spherical collapsing core for an optically thick species and confirmed that the expected blue asymmetric line profile was produced in agreement with previous studies.

Molecular Species
-----------------

The general procedure for creating the molecular line profiles is the following. The filaments from our original simulation are mapped onto a grid and the number density of each desired species is calculated using simplified prescriptions for the abundances as a function of density. The grids are used as inputs for RADMC-3D, which calculates the level populations of the tracer species, and then carries out ray-tracing to calculate the molecular emission. To compute the level populations of our chemical species we use line data obtained from the Leiden LAMDA database [@Schoier05] and assume that molecular hydrogen is the dominant collisional partner.

We consider three molecular species in this study, each having different properties and tracing different regimes, as shown in [Table ]{}\[species\]. The chosen line transitions all lie within the observable range of most ground based detectors, such as ALMA. All transitions have a high critical density, and hence are dense gas tracers. Consequently, any differences in the emitted line profiles are primarily due to optical depth effects.

  ---------------- ------ --------------------- ----------- -------------------------------------
  Tacer            Line   Critical density      Optically   Abundance Law
                          \[cm$^{-3}$\]                     \[n/n$_{H_2}$\]
  [N$_2$H$^+$]{}   1-0    1.4 ${\times 10}^5$   thin        $10^{-10}$
  CS               2-1    3.2 ${\times 10}^5$   thick       $4{\times 10}^{-9} e^{-n_{H2}/n_d}$
  HCN              1-0    2.6 ${\times 10}^6$   thick       $3{\times 10}^{-9}$
  ---------------- ------ --------------------- ----------- -------------------------------------

\[species\]

The isolated component of [N$_2$H$^+$]{} is optically thin and traces the entirety of the dense gas. Molecular collisional rates and the the Einstein coefficients of this species have been calculated by @Daniel05 and @Schoier05. [N$_2$H$^+$]{} has seven hyperfine lines that make up its (1-0) transition. We model the isolated 101-012 hyperfine line, which has a rest frequency of 93.176 GHz. The critical density for LTE is estimated to be $n_{crit}=1.4{\times 10}^5$ cm$^{-3}$, using the relation $n_{crit}=A_{ul}/K_{ul}$ where $A_{ul}$ is the Einstein A coefficient and $K_{ul}$ is the collisional rate (at an assumed kinetic temperature of 20K). As the isolated hyperfine line of [N$_2$H$^+$]{} is optically thin it contains information about all the velocities along the line of sight and no asymmetric infall signature is expected. Nonetheless, this line is a useful reference when compared to optically thick lines to separate self-absorption effects from intrinsic variation in the velocity profiles.

We calculate the abundance of [N$_2$H$^+$]{} using the results of @Aikawa05 who find an abundance of $A_{\mathrm{N2H}^+}=10^{-10}$ relative to the H$_2$ number density of the gas. The abundance of [N$_2$H$^+$]{} has been proposed to rise when CO is frozen onto dust grains as CO destroys [N$_2$H$^+$]{}. For instance @Jorgensen04 found that as CO becomes depleted onto dust grains the abundance of [N$_2$H$^+$]{} increases to $A=10^{-8}$. However, when we used this value for the [N$_2$H$^+$]{} abundance above the CO freeze out density of $n=3{\times 10}^4$ cm$^{-3}$ [@Bergin07], we found that the [N$_2$H$^+$]{} emission became too bright and optically thick compared to its observed behaviour. In @Aikawa05 the [N$_2$H$^+$]{} abundances in collapsing Bonnor-Ebert spheres showed variations of at most a factor of a few, and a slight decrease in abundance at the core centre. Therefore we will use the simple constant abundance model and leave a more detailed analysis of the [N$_2$H$^+$]{} chemistry to future works.

The second molecular tracer is CS, which is optically thick and traces the more diffuse gas in the envelope around the core. Molecular collisional rates and Einstein coefficients for CS were calculated by @Turner92. We model the 2-1 transition of CS, which has


text:
 from four corners of the world.

Studio 12 is a photographic collective is best described as a participatory group of artistindividuals who share in the common objective of developing and sharing their artistic skills through the confluence of differing conceptual and formal approaches that each member brings to the group

Loose Cannon – Amy Friend and Katie Pretti – Psychic Space

An examination of the tension between representation and abstraction, through the work of photographer Amy Friend and painter Katie Pretti.

Curated by Brad Isaacs

Exhibition runs from July 7- 31.

www.loosecanongallery.com

Know Your Ghosts – Jason Lee – The Middle Ground

A Selection of prints and drawings
255 1/2 James Street North Apt. 3
(One night only)

HAMILTON ARTISTS INC – Teri Donovan – Half Life

Co-mingling wallpaper patterns and paint layers, Donovan layers the past with the present to foreshadow a future embedded with forgotten remnants. Old notions, styles, and behaviours, like old wallpaper, are replaced by the new, but are never really gone. In the guise of memory and desire they linger on in a spectral half-life projecting into the future where they emerge to be re-enacted, re-contextualized, and re-interpreted.

Donovan’s work addresses that tenacious desire for life that guarantees the past’s role in the present and the future, and simultaneously suggests how the present secures its own place as it moves towards its inevitable fate.

Exhibition runs until August 14, 2010

Hamilton Hotel- Bryce Huffman Studio

Paintings, Prints and Hugs are all for sale during the art crawl this month. I won’t be there, but Robert Iszkula gives a mean hug!

A number of other studios will be open as well.

The Factory – Ashley Guindon – One Night Only A Great Mystery

Movie Screening, artist in attendence. Curated by Andrew Butkevicius

Artword Artbar – Holly Briesmaster and Janice Jackson – Arcangles

A two-person collaborative exhibition of fans and constructions that explores the arc form.
Friday July 9, artists present 7-10 pm for James North Art Crawl
July 2 to August 1, 2010

Ok so a couple articles about the arts in The Hamilton Spectator, unfortunantely nothing about the Skydragon, (Article here) the one is about Mayor Fred’s travel to Pittsburgh to emulate their success, which was partly due to the art and also leadership. (Strange cause only Brian McHattie responded to my email about the Skydragon- asking if a emergency loan could be made to Skydragon in order to save it. Also weird since Pittsburg helped the arts and Hamilton seems content on letting it linger or die instead.) Strangely Jeremy from the ICCA paid his own way, which again shows how even despite the city the arts do care about Hamilton.

The Other is about Graham Crawford’s History and Heritage posters which oddly make fun of city hall’s dereliction of duty when it come to any sense of history or heritage….. then again why would the city do something normal like I dunno discuss these plans with a community on what should be done? Councillor Lloyd Ferguson seems to think suing people is the answer to democracy and free speech, my personal favorite line from the article is “The posters feature the tag line “Councillor Lloyd Ferguson is the plastic pink flamingo on the front lawn of heritage.”

And finally something to make you, well at least me happy, sorry to keep plugging away about the skydragon but I feel its nessary, anyways… this is a local film about environmental stuff made in Hamilton!!<|endoftext|>376 Crypto Whales Hold 33 Percent of Ether, Chainalysis Finds

Though cryptocurrencies were introduced to create a decentralized economy, a recent study by Chainalysis revealed that one-third of Ether is being held by only 376 people.This makes the digital currency of the smart contracts leader more centralized than Bitcoin as only little more than 20 percent of the leading digital asset is controlled by the so-called crypto whales.Discover Barcelona Trading Conference – A Top Tier Crypto Trading EventAccording to the New York-based blockchain analytics firm, though, in 2019, a handful of individuals control 33 percent of Ether, the concentration of the coin went down significantly as 47 percent of the same was held by the whales in 2016.The company defines “whales” as the “the top 500 holders” of cryptocurrency, however, it excluded the custodian services which store huge amount of crypto holdings off the exchanges.Little impact on the marketDespite the concentration of the cryptocurrency, its impact is limited to the price of the asset.

“These whales have no meaningful impact on the price of Ether; they do, however, make the market more volatile on a daily basis with their large sell-offs,” the company explained.Suggested articlesX Open Hub Deploys New Trading Infrastructure in Asia, Hong KongGo to article >>The study elaborated that the whales largely hold the digital currency and account for between 5 to 8 percent of economic transaction volume of Ether.Furthermore, market data collected from 2016 to 2019 revealed that the value of Ether tends to follow the price movement of Bitcoin.

“On average, a 1% increase in Bitcoin prices yesterday leads to a 1.1% increase in Ether prices today,” Chainalysis stated.However, the movement of funds by these whales impact the intraday volatility of the market.“On average, a whale that sends 1 million USD worth of ether two days ago leads to a 0.1 unit increase in intraday volatility today, which is relatively small considering values of intraday volatility range from 0.02 minimum to 417 maximum,” the analytics company added.Recently, the former CTO of TRON revealed that the project has deviated from the principles of decentralization and its voting process is being controlled by a handful of people.“We cannot rule out the possibility that whales can impact price changes within single days based on outlier events,” Chainalysis concluded.<|endoftext|>"use strict";

Object.defineProperty(exports, "__esModule", {
  value: true
});
exports.default = removeProperties;

var _constants = require("../constants");

const CLEAR_KEYS = ["tokens", "start", "end", "loc", "raw", "rawValue"];

const CLEAR_KEYS_PLUS_COMMENTS = _constants.COMMENT_KEYS.concat(["comments"]).concat(CLEAR_KEYS);

function removeProperties(node, opts = {}) {
  const map = opts.preserveComments? CLEAR_KEYS : CLEAR_KEYS_PLUS_COMMENTS;

  for (const key of map) {
    if (node[key]!= null) node[key] = undefined;
  }

  for (const key of Object.keys(node)) {
    if (key[0] === "_" && node[key]!= null) node[key] = undefined;
  }

  const symbols = Object.getOwnPropertySymbols(node);

  for (const sym of symbols) {
    node[sym] = null;
  }
}<|endoftext|>From babywear to wedding rings, ISIS supporters have been showing off their appalling taste in fashion on social media.

Most ISIS merchandises appear to be cheaply made and poor quality, always adorned with the ISIS badge.

The uninspiring fashion pieces have been seen being worn by fighters, mothers and babies living in ISIS territory in Syria and Iraq.

ISIS Infant: Jihadi mothers have regularly posted pictures of their babies wrapped up in an assortment of terrible fashion creations.

Indoctrinated: Young babies have been pictured, miserably wrapped in Islamic State flags and an assortment of ill fitting hats.

Naturally nearly all the merchandises are based around the dull colour scheme of black and white.

The uninspiring colours embody the values of the extremist group’s flag, the famous black banner long associated with Islamic State and radical Islam.

Any other colour could be a hint of apostasy, or worse interest in the tight fitting world of Western clothes.

From schoolbags to berets, ISIS's vile taste in fashion and merchandises knows no limits.

Jihadi mothers in Syria and Iraq obsessively show off their little darlings, decked out in Islamic State’s latest naff fashion pieces.

Young babies have been pictured, miserably wrapped in Islamic State rugs, highlighting the extremist group’s obsession with indoctrinating children from a young age.

Oblivious to their unexplained allegiance to the group, their heads have been covered with an itchy looking hats with the ISIS logo emblazoned on in Arabic.

Unaware of their fashion faux pas, some kids have been forced to wear mini ISIS military uniforms and t-shirts.

Oblivious to their unexplained allegiance to the group, this ISIS child's head has been covered with an itchy looking hat, emblazoned with 'God is Great' in Arabic.

Other children have been kitted out in ill-fitting military uniforms, struggling to hold onto the rifle which has been thrusted into their arms for the photo.

School children have been photographed, proudly wearing ISIS branded school bags as they walk to school.

One young girl is pictured posing from behind to show off her own ISIS draw string bag.


text:
 to set up an SMTP server on one of my test boxes. Postfix is installed and running, however, when I try to end a message it just does not work. All the documentation I've seen says that when you insert a "." (period) on a new line in the body, the message will be sent. This just does not work for me, though. The program just goes onto the next line as if expecting more text.

A:

Assuming your problem does occur while doing telnet localhost 25 your session has to look like this:
(...)
DATA
354 End data with <CR><LF>.<CR><LF>
Subject: Test

This is the body
.
250 2.0.0 Ok: queued as 6E9B019E46

And this works trillions of time every day.

<|endoftext|>The polarization of fluorescence of DNA stains depends on the incorporation density of the dye molecules.
The fluorescence induced by polarized light sources, such as the lasers that are used in flow cytometry, is often polarized and anisotropic. In addition, most optical detector systems are sensitive to the direction of polarization. These two factors influence the accuracy of fluorescence intensity measurements. The intensity of two light sources can be compared only if all details of the direction and degree of polarization are known. In a previous study, we observed that fluorescence polarization might be modified by dye-dye interactions. This report further investigates the role of dye density in fluorescence polarization anisotropy. We measured the polarization distribution of samples stained with commonly used DNA dyes. To determine the role of fluorophore proximity, we compared the monomeric and a dimeric form of the DNA dyes ethidium bromide (EB), thiazole orange (TO), and oxazole yellow (YO). In all dyes sampled, fluorescence polarization is less at high dye concentrations than at low concentrations. The monomeric dyes exhibit a higher degree of polarization than the dimeric dyes of the same species. The polarization of fluorescence from DNA dyes is related to the density of incorporation into the DNA helix. Energy transfer between molecules that are in close proximity loosens the linkage between the excitation and emission dipoles, thereby reducing the degree of polarization of the emission.<|endoftext|>Q:

Objective-C in,out,inout,byref,byval,.. and so on. What are they?

I discovered something unfamiliar while reading Objective-C manual for @encoding.
Table 6-2  Objective-C method encodings
Code Meaning
r    const
n    in
N    inout
o    out
O    bycopy
R    byref
V    oneway

The only thing I know is oneway. What are the others?

A:

Those are annotations for method parameters and return values which were used by Distributed Objects. I say were because apparently there’s no sign of them in Apple’s documentation any longer. There used to be a Remote Messaging section in The Objective-C Programming Language document, which is still referenced by the Distributed Objects Programming Topics document.

in: argument is an input argument only and won’t be referenced later
out: argument is an output argument only, used to return a value by reference
inout: argument is both an input and output argument
const: the (pointer) argument is constant
bycopy: instead of using a proxy/NSDistantObject, pass or return a copy of the object
byref: use a proxy object (default)

A:

Beyond Distributed Objects, one of these annotations appears to be used by ARC. I came across the following in clang's description of passing to an out parameter by writeback:

If the parameter is not an Objective-C method parameter marked out, then *p is read, and the result is written into the temporary with primitive semantics.

This has to do with methods like - (BOOL)executeWithError:(out NSError **)error.
Ignoring the out keyword, ARC has a well-defined behavior of treating by-reference object passing as __autoreleasing, so ARC treats the error parameter as having a type of NSError * __autoreleasing *.  If you use an otherwise qualified variable, ARC will add a temporary autoreleasing variable pass into the function (for coherence):
Original code
NSError *error;
[obj executeWithError:&error];

Pseudotransformed code
NSError * __strong error;
NSError * __autoreleasing temp;
temp = error;
[obj executeWithError:&temp];
error = temp;

With the above code, the line temp = error would be unnecessary if we could somehow know that temp will never be read.  This is where the out annotation comes into play.  Per the quoted description if out is missing the compiler must add the line temp = error but if it does contain out it can exclude the line and make the code just a little bit smaller/faster.  With out the transformed code becomes:
NSError * __strong error;
NSError * __autoreleasing temp;
[obj executeWithError:&temp];
error = temp;

Of course, if you're that worried about binary size and speed, you should just code the following:
NSError * __autoreleasing error;
[obj executeWithError:&error];

It is entirely possible that these annotations are used other places throughout the compiler and runtime, and may be used in more places in the future.  Personally, I like using out as a hint to other developers that I'm not going to read the value.

<|endoftext|>INTRODUCTION {#s1}
============

Hepatocellular carcinoma (HCC) ranks fifth among the most common cancer globally and is the third most frequent cause of cancer deaths \[[@R1]--[@R2]\]. A common complication of HCC is the Portal vein tumor thrombus (PVTT) that results in a poor median survival of 2.7--4.0 months and is reported in 64.7% cases at autopsy \[[@R3]--[@R6]\]. The poor prognosis associated with PVTT is due to increased risk of tumor spread; variceal hemorrhage as a result of increased portal venous blood pressure; and complications including ascites, jaundice, hepatic encephalopathy, and liver failure due to decreased portal flow \[[@R7], [@R8]\]. Further, since PVTT is a contraindicator for transplantation and curative resection according to the HCC treatment guidelines, the treatment options are limited \[[@R9]--[@R10]\]. Therefore, the standard management for HCC patients with PVTT is controversial \[[@R8], [@R10], [@R11]\].

The efficacy of sorafenib, which is the recommended therapy for HCC patients with PVTT according to the Barcelona Clinic Liver Cancer staging system, is limited \[[@R12]--[@R13]\]. However, patients with PVTT that underwent transarterial chemoembolization (TACE) in addition to sorafenib demonstrated better survival according to some studies \[[@R14]--[@R15]\]. Therefore, TACE therapy is considered for advanced-stage HCC patients \[[@R1], [@R16]--[@R17]\]. However, since sorafenib is expensive, the majority of patients in China with advanced HCC (with PVTT) cannot afford such treatment, and therefore, there is an urgent need for an alternative and more cost-effective treatment.

Yang *et al*. reported that TACE in combination with endovascular implantation of a ^125^iodine seed strand was a feasible and effective treatment for HCC patients with PVTT \[[@R19]\]. Some studies reported computed tomography (CT)-guided ^125^iodine implantation in HCC patients with PVTT \[[@R20]--[@R21]\]. The two methods are different, and direct CT-guided ^125^iodine implantation in PVTT is technically easier to perform. However, these studies included very few cases of CT-guided ^125^iodine seed implantation in PVTT without any control group or analysis of long-term outcomes.

Thus, we evaluated the safety and efficacy of TACE combined with direct CT-guided ^125^iodine implantation in PVTT (TACE-^125^iodine) in a retrospective cohort study of HCC patients that had PVTT only in the right or left portal vein branch and absent in the main portal vein.

RESULTS {#s2}
=======

Patient characteristics {#s2_1}
-----------------------

Out of 137 patients with unresectable HCC with type B PVTT that underwent either TACE-^125^iodine or TACE only, 37 were excluded because they did not meet the inclusion criteria (Figure [1](#F1){ref-type="fig"}). As a result, we studied 100 patients (TACE-^125^iodine, n=50; TACE only, n=50) that qualified for our analysis. Detailed baseline patient characteristics are shown in Table [1](#T1){ref-type="table"}. The baseline characteristics between the TACE-^125^iodine and the TACE only groups were not statistically different. The mean follow-up duration for the TACE-^125^iodine group was 24.2 months (range, ≤1 month to 56 months) and 6.3 months (range, ≤1 month to 18 months) for the TACE only group. During the follow-up, 44 of the 50 patients (88%) in the TACE-^125^iodine group and 49 of the 50 patients (98%) in the TACE only group died. Five (10%) of the 50 patients underwent repeated ^125^iodine seed implantation with a mean


text:
 Fig. \[trans\_triangle\]. The nodes of the triangle represent the three ways of representing a signal and the edges represent the canonical transformation used for the conversion between them. The conversion between the time and frequency representations is through the Fourier transform, and the conversion of the delay-Doppler representation to the time and frequency representations is through the Zak transforms $Z_t$ and $Z_f$, respectively. It is important to note that the composition of any pair of transforms is equal to the remaining one. For example, the Fourier transform is a composition of two Zak transforms ($\mbox{FT}=Z_t\circ Z_f^{-1}$). The signals in the delay-Doppler domain can be viewed as functions $\phi(\tau,\nu)$ on a two-dimensional delay-Doppler plane whose points are parametrized by $\tau$ and $\nu$. This representation is a quasi-periodic representation and has an associated delay period $\tau_r$ and a Doppler period $\nu_r$, such that $\tau_r \nu_r=1$. The delay-Doppler representation can be converted to time and frequency representations by Zak transforms $Z_t$ and $Z_f$, respectively, given by [@otfswhitepaper] $$Z_t(\phi)= \hspace{-1mm} \int_0^{\nu_r} \hspace{-3mm} e^{j2\pi t \nu} \phi(t,\nu) \mathrm{d} \nu, \ \
Z_f(\phi)=\hspace{-1mm} \int_0^{\tau_r} \hspace{-3mm} e^{-j2\pi \tau f} \phi(\tau,f) \mathrm{d} \tau.$$

![The fundamental transform triangle.[]{data-label="trans_triangle"}](transform_triangle.eps){width="5cm" height="2.5"}

A fundamental feature of OTFS modulation that distinguishes it from other time-frequency (TF) modulation schemes is the use of delay-Doppler domain for multiplexing the modulation symbols. These symbols in the delay-Doppler domain can be converted into time domain using the Zak transform $Z_t$. The transformation that uses a single Zak transform to convert a signal in delay-Doppler domain to a signal in time domain can also be carried out in two steps. That is, the signal in the delay-Doppler domain is first transformed to time-frequency domain, and the resulting time-frequency signal is converted to a time domain signal using a second transformation. As a consequence of this two step transformation, OTFS modulation can be implemented using simple pre- and post-processing steps over any multicarrier modulation scheme such as OFDM. The series of transformations involved in OTFS modulation transforms a time varying multipath channel into a slowly varying channel in the delay-Doppler domain. The complex baseband channel response in the delay-Doppler domain is denoted by $h(\tau,\nu)$, where $\tau$ and $\nu$ are the delay and Doppler variables, respectively. With this representation, the received signal $y(t)$ due to a transmit signal $x(t)$ is given by $$\label{channel}
y(t)=\int_{\nu} \int_{\tau} h(\tau,\nu)x(t-\tau)e^{j2\pi\nu(t-\tau)} \mathrm{d} \tau \mathrm{d} \nu.$$ The channel coefficients in this representation correspond to the group of reflectors associated with a particular delay depending on reflectors’ relative distance and Doppler value depending on its relative velocity. Since the velocity and the relative distance remain roughly the same for a relatively longer duration, the delay-Doppler channel coefficients are time invariant for a larger observation time as compared to that in time-frequency representation [@otfs1]. Also, the delay-Doppler representation of the channel impulse response yields a sparse representation of the channel, thus requiring only fewer channel parameters to be estimated. With this, we now proceed to the description of the OTFS modulation scheme architected using pre- and post-processing operations over a multicarrier modulation.

![image](OTFS_block_diagram_1.eps){width="12.5" height="3.0"}

The block diagram of the OTFS modulation scheme is shown in Fig. \[blkdiag\]. The inner box in the block diagram is the familiar multicarrier TF modulation and the outer box with pre- and post-processor is the OTFS modulator that operates in the delay-Doppler domain. At the transmitter, the information symbols (e.g., QAM symbols) denoted by $x[k,l]$ residing in delay-Doppler domain are mapped to the TF signal $X[n,m]$ through the 2D inverse symplectic finite Fourier transform (ISFFT) and windowing. Subsequently, this TF signal is transformed into a time domain signal $x(t)$ through Heisenberg transform for transmission. At the receiver, the received signal $y(t)$ is transformed back to a TF domain signal $Y[n,m]$ through Wigner transform (inverse Heisenberg transform). The TF signal $Y[n,m]$ thus obtained is mapped to the delay-Doppler domain signal $y[k,l]$ using the symplectic finite Fourier transform (SFFT) for demodulation. In the subsequent subsections, we describe the TF modulation and the OTFS modulation in detail.

Time-frequency modulation {#sec2b}
-------------------------

-   The time-frequency plane is sampled at intervals $T$ and $\Delta f$, respectively, to obtain a 2D lattice or grid $\Lambda$, which can be defined as $\Lambda=\lbrace(nT,m\Delta f), n=0,\cdots,N-1, m=0,\cdots, M-1\rbrace$.

-   The signal in TF domain $X[n,m]$, $n=0,\cdots,N-1$, $m=0,\cdots,M-1$ is transmitted in a given packet burst, which has duration $NT$ and occupies a bandwidth of $M\Delta f$.

-   Let $g_{tx}(t)$ and $g_{rx}(t)$ denote the transmit and receive pulses, respectively. We assume $g_{tx}(t)$, $g_{rx}(t)$ to be ideal pulses satisfying the bi-orthogonality property with respect to translations by integer multiples of time $T$ and frequency $\Delta f$, i.e., $$\int e^{-j2\pi m\Delta f(t-nT)}g^*_{rx}(t-nT)g_{tx}(t) dt=\delta(m)\delta(n).
    \label{biorth}$$ The bi-orthogonality property of the pulse shapes ensures that the cross-symbol interference is eliminated in the symbol reception. Although ideal pulses cannot be realized in practice, given the constraint imposed by the uncertainty principle, they can be approximated by the pulses whose support is highly concentrated in time and frequency [@otfs4]. Design of pulses concentrated in time and frequency to minimize the cross-symbol interference has been discussed in [@pulse_design1],[@pulse_design2].

-   TF modulation: The signal in TF domain $X[n,m]$ is transformed to the time domain signal $x(t)$ through the Heisenberg transform, given by $$\hspace{-0mm}
    x(t)= \sum_{n=0}^{N-1} \sum_{m=0}^{M-1} X[n,m]g_{tx}(t-nT)e^{j2\pi m \Delta f (t-nT)}.
    \label{tfmod}$$

-   TF demodulation: At the receiver, the sufficient statistic for symbol detection is obtained by matched filtering the received signal with the receive pulse $g_{rx}(t)$. This requires the computation of the cross-ambiguity function $A_{g_{rx},y}(\tau,\nu)$, given by $$\label{crossambig}
    A_{g_{rx},y}(\tau,\nu)=\int g_{rx} ^*(t-\tau) y(t) e^{-j2 \pi \nu(t-\tau)} \mathrm{d}t.$$ Sampling this function on the lattice $\Lambda$ yields the matched filter output, given by $$\label{wigner}
    Y[n,m] = A_{g_{rx},y}(\tau,\nu)|_{\tau =nT,\nu =m \Delta f}.$$ Equation (\[wigner\]) is called the Wigner transform, which can be looked at as the inverse of the Heisenberg transform. A detailed discussion on Heisenberg and Wigner representations and its applications in communication theory has been presented in [@Heisenberg],[@rep_theory].

-   If $h(\tau,\nu)$ has finite support bounded by $(\tau_{\mbox{\scriptsize{max}}},\nu_{\mbox{\scriptsize{max}}})$ and if $A_{g_{rx}g_{tx}}(\tau,\nu)=0$ for $\tau \in (nT-\tau_{\mbox{\scriptsize{max}}},nT+\tau_{\mbox{\scriptsize{max}}})$, $\nu \in (m\Delta f-\nu_{\mbox{\scriptsize{max}}},m\Delta f+\nu_{\mbox{\scriptsize{max}}})$, $\forall n,m$ except for $n=0, m=0$ where $A_{g_{rx}g_{tx}}(\tau,\nu)=1$, the relation between $Y[n,m]$ and $X[n,m]$ for TF modulation can be derived as [@otfs1a] $$\label{tfin


text:
 any future $w$. It follows that $\bar{p}$ will not be picked in any future iteration.

Since for all $p \in Q$ we have $|u_{p}| \in \{0, \ldots, k-1\}$, the algorithm performs at most $k$ loop iterations. Hence, using \[lem-extender-restivo\], the computed word $z$ has length at most $k \cdot \frac12 (k-1) (n+2) n + (k-1) \le \frac12 k (k-1) (n+2) (n+1)$. The argument for $y$ is similar.

The following lemma adapts \[lem-sc-main\]:

\[lem-sc-main-restivo\] One can compute in polynomial time a killing word of length at most $(k+1) k^2 (n+2) (n+1)$.

Let $z,y$ be the words from \[lem-extender-all-restivo\]. We can assume that $|z| \ge k-1$. First we argue that there are at most $k$ states that are reached by $y$ and survive $z$. Towards a contradiction, suppose otherwise. By the pigeonhole principle, there are two distinct states $q, q' \in Q$ that are reached by $y$ and survive $z$ and satisfy $|u_q| = |u_{q'}|$. Since $|z| \ge k-1$, it follows that $u_q = u_{q'}$ is a prefix of $z$, thus $q,q'$ are mergeable. But $q,q'$ are reached by $y$, contradicting the definition of $y$.

It follows that the $k$ from \[sub-sc\] is at most the $k$ from this section. Mirroring exactly the proof of \[lem-sc-main\] and using \[lem-extender-all-restivo\], we obtain a killing word $w$ of length at most $$\begin{aligned}
 |w| &\ \le \ |y z| + k (n + |y z|) \ \le \ n^2 + (k+1)(|y|+|z|) \\ &\ \le \ n^2 + (k+1) k (k-1) (n+2) (n+1) \ \le \ (k+1) k^2 (n+2) (n+1)\,.\end{aligned}$$

Finally we prove \[thm-restivo\]:

Since $k > 0$, it follows $|X| \ge 1$ and thus $n = m - |X| + 1 \le m$. The result follows from \[lem-sc-main-restivo\].

Proof of Theorem \[thm-long-product\] {#sec-proof-long-product}
=====================================

Denote by $p_i$ the $i$th prime number (so $p_1 = 2$). Let $m \ge 1$. Define: $$\begin{aligned}
\Sigma \ &:= \ \{a, b_1, \ldots, b_m\} \\
Q_i \    &:= \ \{(i,0), (i,1), \ldots, (i,p_i-1)\} \quad \text{for every } i \in \{1, \ldots, m\} \\
Q \      &:= \ \{0\} \cup \bigcup_{i=1}^m Q_i\end{aligned}$$ Further, define a monoid morphism $M : \Sigma^* \to {\mathbb{N}}^{Q \times Q}$ by setting for all $i \in \{1, \ldots, m\}$ $$\begin{aligned}
M(a)(0,(i,0)) \ &:= \ 1 \\
M(a)((i,j),(i,j+1 \bmod p_i)) \ &:= \ 1 \quad\text{ for all } j \in \{0, \ldots, p_i-1\} \\
M(b_i)(0,0) \ &:= \ 1 \\
M(b_i)((i,j),0) \ &:= \ 1 \quad\text{ for all } j \in \{0, \ldots, p_i-1\}\end{aligned}$$ and setting all other entries of $M(a), M(b_1), \ldots, M(b_m)$ to $0$, see \[fig-M3\].

\(0) at (0.4,0.8) [$0$]{}; (10) at (1,0) [$(1,0)$]{}; (11) at (1,-1) [$(1,1)$]{}; (20) at (2,0) [$(2,0)$]{}; (21) at (2,-1) [$(2,1)$]{}; (22) at (2,-2) [$(2,2)$]{}; (30) at (3,0) [$(3,0)$]{}; (31) at (3,-1) [$(3,1)$]{}; (32) at (3,-2) [$(3,2)$]{}; (33) at (3,-3) [$(3,3)$]{}; (34) at (3,-4) [$(3,4)$]{}; (r1) at (1.4,-1.7); (l1) at (0.4, -1.7); (r2) at (2.4,-2.7); (l2) at (0.4, -2.7); (r3) at (3.4,-4.7); (l3) at (0.4, -4.7); (0) edge \[loop,out=160,in=200,looseness=4\] node\[left\] [$b_1,b_2,b_3$]{} (0); (10) edge node\[left\] [$a$]{} (11); (20) edge node\[left\] [$a$]{} (21); (21) edge node\[left\] [$a$]{} (22); (30) edge node\[left\] [$a$]{} (31); (31) edge node\[left\] [$a$]{} (32); (32) edge node\[left\] [$a$]{} (33); (33) edge node\[left\] [$a$]{} (34); (11) – +(-0.4,0) – node\[right\] [$a$]{} ($ (10) + (-0.4,0) $) – (10); (22) – +(-0.4,0) – node\[right\] [$a$]{} ($ (20) + (-0.4,0) $) – (20); (34) – +(-0.4,0) – node\[right\] [$a$]{} ($ (30) + (-0.4,0) $) – (30); (11) -| (r1) – node\[above\] [$b_1$]{} (l1) – (0); (10) -| (r1) -| (0); (22) -| (r2) – node\[above\] [$b_2$]{} (l2) – (0); (21) -| (r2) -| (0); (20) -| (r2) -| (0); (34) -| (r3) – node\[above\] [$b_3$]{} (l3) – (0); (33) -| (r3) -| (0); (32) -| (r3) -| (0); (31) -| (r3) -| (0); (30) -| (r3) -| (0); (0) – node\[above,pos=0.45\] [$a$]{} +(0.6,0) – (10); (0) -| (20); (0) -| (30);

We have $M(\Sigma^*) \subseteq \{0, 1\}^{Q \times Q}$, i.e., $M(\Sigma^*)$ is an unambiguous monoid of relations. For all $q \in Q$ and all $q' \in Q \setminus \{0\}$ we have $M(b_1)(q,q') = 0$, i.e., $M(b_1)$ has rank $1$. For all $w \in \Sigma^*$ there is $q \in Q$ with $M(w)(0,q) = 1$, i.e., $1$ is the minimum rank in $M(\Sigma^*)$. A shortest word $w_0 \in \Sigma^*$ such that $M(w_0)$ has rank $1$ and $M(w_0)(0,(i,p_i-1)) = 1$ holds for all $i \in \{1, \ldots, m\}$ is the word $w_0 = b_1 a^P$ where $P = \prod_{i=1}^m p_i \ge 2^m$. On the other hand, we have $|Q| = 1 + \sum_{i=1}^m p_i \in O(m^2 \log m)$ by the prime number theorem.

Hence there is no polynomial $p$ such that $P \le p(|Q|)$ holds for all $m$.


text:
±1907.7                              7532±1683.3                           0.58
  Meloxicam              59.9±9.14       6662±1772.2                              8272±2744.4                           0.052
  ---------------------- --------------- ---------------------------------------- ------------------------------------- ---------

![Variations of the GPx activity in the group of subjects treated with piroxicam.](CHSJ-42-01-04-fig2){#F2}

![Variations of the GPx activity in the group of subjects treated with tenoxicam.](CHSJ-42-01-04-fig3){#F3}

![Variations of the GPx activity in the group of subjects treated with meloxicam.](CHSJ-42-01-04-fig4){#F4}

![Variations of the GPx activity (mean) in piroxicam, tenoxicam, and meloxicam treated groups.](CHSJ-42-01-04-fig5){#F5}

Discussion
==========

The conducted studies regarding the influence of NSAIDs on GPx are rather few, and the activity of this enzyme has registered insignificant variations \[[@B17],[@B18]\].

The tenoxicam activity of neutralization for hydroxyl, superoxide, and peroxyl radicals, which are involved into inflammatory reactions, was tested in vitro in many types of non-cellular systems. This drug has demonstrated its property of scavenging the hydroxyl radical and the superoxide in vitro \[[@B19]\]. Orhan and Sahin found that piroxicam, ketorolac, naproxen and tiaprofenic acid determine a significant inhibition of the glutathione peroxidase from human erythrocytes in vitro \[[@B20]\]. Van Antwerpen and Nève have studied in vitro scavenging effect of ROS for piroxicam, tenoxicam, lornoxicam, meloxicam, nimesulid and ibuprofen. They discovered that piroxicam has an antioxidant activity higher than tenoxicam, ibuprofen and nimesulid \[[@B21]\]. Agha et al. observed an increased of the GPx plasmatic activity, in rats with experimental induced arthritis \[[@B22]\]. Bartosiewicz et al. realized that piroxicam produces significant changes of the GPx activity in patients with rheumatoid arthritis \[[@B23]\]. In a clinical study realized on patients with osteoarthritis it was observed that piroxicam determined a significant increase in superoxide dismutase activity \[[@B24]\], celecoxibe induced a decrease in the GPx activity, while tenoxicam determined an increase in the GPx activity, with no significance from the statistical point of view \[[@B25]\].

In this present clinical study, the values of GPx presented a slightly increase in all groups of subjects. From all oxicams, meloxicam had the highest influence (p = 0.052), even if the variation was not statistically significant (p \> 0.05).

Conclusions
===========

This present clinical study revealed that the activity of glutathione peroxidase, a member of the antioxidant systems, increased after 20 days of treatment with piroxicam, meloxicam and tenoxicam, respectively, as compared to baseline. However, none of these three NSAIDs belonging to oxicam class had a statistically significant influence on the GPx activity in patients with knee osteoarthritis.

COX inhibition alone did not seem to fully explain the antioxidant effects demonstrated by the NSAIDs including oxicams, although free radicals were generated during the prostaglandin synthesis from arachidonic acid under the influence of COX. This fact suggested an additional mechanism of action on the oxidative stress, independent of COX inhibition which might provide new therapeutic ways for osteoarthritis treatment.
<|endoftext|>Dementia, depression, or grief? The differential diagnosis.
Depression, grief, and dementia are conditions frequently encountered among the community-living elderly. This review offers a primary care perspective of the distinguishing features for each and discusses the special issues of managing the elderly. Major depression in the elderly usually responds to antidepressant medication, whether the depression occurs alone (endogenous) or as a response to another condition (reactive).<|endoftext|>
18 F.2d 879 (1927)
COMMONWEALTH CASUALTY CO.
v.
AICHNER.[*]
No. 7525.
Circuit Court of Appeals, Eighth Circuit.
April 5, 1927.
Walter L. Roos, of St. Louis, Mo. (Thomas H. Cobbs, George B. Logan, Charlton A. Alexander, and James V. Dunbar, all of St. Louis, Mo., on the brief), for plaintiff in error.
Walter H. Saunders, of St. Louis, Mo. (John S. Leahy, Lambert E. Walther, Harold F. Hecker, and Lyon Anderson, all of St. Louis, Mo., on the brief), for defendant in error.
Before STONE and VAN VALKENBURGH, Circuit Judges, and TRIEBER, District Judge.
VAN VALKENBURGH, Circuit Judge.
Defendant in error is the widow of one R. F. Aichner, who was drowned while swimming on August 10, 1924. June 16, 1924, plaintiff in error issued to the deceased the policy of insurance upon which this suit is founded. That policy, on its face, is called "Peerless Special Ten-Dollar Accident and Sickness Policy." In consideration of a premium payment of $10, plaintiff in error undertook to insure the husband of defendant in error for the term of one year "against the effects of bodily injuries caused directly, solely, and independently of all other causes by external, violent, and accidental means, which bodily injuries or their effects shall not be caused wholly or in part, directly or indirectly, by any disease, defect, or infirmity, and which shall from the date of the accident result in continuous disability and also against the effects of sickness, as follows:

                   "Section A. Accidents Benefits.
                                   Value First    Annual Increase    Value After Fifth
                                    Year under         under             Year under
                                    Section A        Section A           Section A
  For loss of life............... $5,000.00       $500.00            $7,500.00
  For loss of both hands
   by complete severance
   at or above the wrists........  3,500.00        350.00             5,250.00
  For loss of both feet by
   complete severance at
   or above the ankles...........  3,500.00        350.00             5,250.00
  For loss of one hand and
   one foot by complete
   severance as defined
   above.........................  3,500.00        350.00             5,250.00
  For loss of entire sight
   of both eyes, if irrecoverably
   lost..........................  3,500.00        350.00             5,250.00
  For loss of either hand
   by complete severance
   at or above the wrist.........    875.00         87.50             1,312.50
  For loss of either foot
   by complete severance
   at or above the ankle.........    875.00         87.50             1,312.50
  For loss of entire sight
   of one eye, if irrecoverably
   lost..........................    375.00         35.00               550.00

*880  resulting within thirty days from date of accident solely from such injuries, which shall have caused continuous total disability from date of accident to date of loss, but only when such injuries are sustained.
"WHILE TRAVELING as a passenger in a place regularly provided for passengers, within any common carrier's public passenger conveyance (animals, aerial machines, or conveyances excepted), but only when such injuries are sustained by reason of the wrecking of such conveyance."
Section B provides indemnity of $50 per week, not exceeding 10 consecutive weeks, for loss of time for injuries sustained in the same manner as provided in section A.
Section C provides indemnity of $25 per week, not exceeding 10 consecutive weeks, for loss of time from injuries sustained in the manner specified in said section C, which differs from that specified in sections A and B.
Section D provides indemnity for the fracture of any bone by accident in or out of business, except such as are covered under sections A, B, or C.
Section E provides hospital benefits resulting from injuries caused by any accident for which no other indemnity is provided by the policy.
Section F agrees to pay for loss of life from any accident not otherwise covered by the policy.
Section G deals with surgeon's fees; section H, with sickness benefits; section I, with emergency benefit, in case the insured is physically unable to communicate with friends.
Section J, under the heading "General Provisions," specifies persons and conditions, employments, etc., not covered by the policy.
Defendant in error brought suit to recover the principal sum of $5,000, being the first year value for loss of life specified under section A above quoted, together with interest and a penalty of $500 for alleged vexatious refusal to pay the said policy, and a reasonable attorney's fee, to be determined at the trial. Plaintiff in error denied liability under section A, and tendered payment of $100 under section F of the policy. A jury was waived in writing and the case was tried to the court upon an agreed statement of facts. Judgment was entered for defendant in error


text:
icks at the *trs* (white star) (B). A replication complex is assembled and replication commences through the ITR towards the vector (C). The new synthesized ITR fold into a hairpin conformation displacing the replication strand. Such displacement determines a template switch so that the originally nicked strand is copied during replication. The replication passes through the other ITR and proceeds into the vector sequence (D). After replication fork has completed a full circle, Rep produces a second nick and the newly synthesized DNA is displaced as ssDNA (E). The new ssDNA is nicked again and two ssDNA containing only one complete ITR are formed (F). The missing ITR is repaired by gene correction mechanism (G).](pone.0023474.g008){#pone-0023474-g008}

Why does the yeast produce such high level of ssDNA? Is that due to an accumulation process of the newly formed ssDNA or is the mechanism leading to ssDNA formation more efficient in *Saccharomyces cerevisiae* than in human cells? The answer to these questions is not very easy but understanding the cellular factors involved in the ssDNA formation may be crucial for AAV encapsidation. It is known that yeast is very efficient in DNA repair mediated by homologous recombination. Yalkinoglu et al. [@pone.0023474-Yalkinoglu1] have shown that a plasmid containing the extreme left half of AAV with a single ITR could replicate in cells treated with genotoxic reagents suggesting a possible role of DNA damage repair in this process. Moreover, in cultured human cells, a marked increase in rAAV transduction efficiency is obtained by treating cells with agents that affect genomic DNA integrity or metabolism, such as UV irradiation, hydroxyurea (HU), topoisomerase inhibitors and several chemical carcinogens [@pone.0023474-Alexander1], [@pone.0023474-Alexander2], [@pone.0023474-Zhou1], [@pone.0023474-Zentilin1]. It has been demonstrated recently that MRE11 complex, which is primarily involved in DNA double strand break repair, binds the incoming ssAAV genome and poses a barrier to AAV and that the helper function provided by the adenoviral proteins E1b55K/E4orf6 involves the degradation of MRE11 complex [@pone.0023474-Cervelli1], [@pone.0023474-Schwartz1]. These observations suggest that in human cells MRN complex can have a role in the rescue of AAV from plasmid. The higher efficiency of the non-homologous end-joining apparatus in mammalian cells, related to the strong pressure to repair double-strand breaks in these large genomes, probably explains the ability of AAV to grow in these cells only when that apparatus is partially saturated by double-strand break events. This requirement is apparently not present in yeast that yet seemingly contains all the cellular factors necessary for AAV genome replication in the right balance. In yeast, double strand breaks are mainly repaired by homologous recombination so the MRN complex proteins are available for other processes and could be immediately engaged in ssDNA formation. The formation of ssDNA does not occur immediately after pAAV plasmid transformation and required the replication of the plasmid. In fact, we did not detect any ssDNA in yeast cells 3 or 24 hours after transformation (data not shown). Therefore, we can speculate that the formation of ssDNA initiates after the plasmid has been replicated. It could be interesting to study AAV ssDNA genome in yeast cells with different genetic background. Thus, the utilization of this organism could allow not only to study the cellular requirements for viral production, but, not less importantly, to overcome the present limitations to produce rAAV for targeted gene therapy, since it is safe, cheap and amenable to easy manipulate the host.

We can thus conclude that the AAV genome can replicate in *Saccharomyces cerevisiae*; this is not surprising because yeast may replicate DNA genomes for other such as *Human papilloma virus* [@pone.0023474-Angeletti2] and the ssDNA genome, *Indian Mung Bean Yellow Mosaic virus* [@pone.0023474-Raghavan1].

The authors wish to thank Matthew Weitzman and Toni Cathomen for plasmid expressing Rep proteins. The authors also thank Peter Angeletti and Lorena Zentilin for helpful suggestions, and Robert Schiestl for the yeast strain. We are grateful to Marcella Simili for critically reading of the manuscript. Tiziana Cervelli is a Fellow of the Foundation of the European Institute of Oncology (Milan, Italy) and Istituto di Fisiologia Clinica, CNR, Pisa, Italy.

We would like to dedicate this paper to our colleague and friend Arturo Falaschi who suddenly died on the 2^nd^ of June 2010. He really believed in this project and strongly stimulated us to go on with experiments.

**Competing Interests:**The authors have declared that no competing interests exist.

**Funding:**The work was supported by the Grant n. GGP09166 assigned from Telethon-Italy to AG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

[^1]: Conceived and designed the experiments: TC AB AG. Performed the experiments: TC AB AG. Analyzed the data: TC AB AG. Contributed reagents/materials/analysis tools: TC AB AG. Wrote the paper: TC AB AG.
<|endoftext|>I AM SELLING MY JOHN DEERE 4115 COMPACT TRACTOR. IT ONY HAS 176 HOURS ON IT. THIS HAS THE 3 CYLINDER DIESEL ENGINE, HYDROSTATIC DRIVE, 4 WHEEL DRIVE. HAS A JOHN DEERE 410 LOADER INSTALLED THAT IS EASY TO REMOVE. ALSO HAS POWER BEYOND HYDRAULICS TO RUN THE JOHN DEERE 46 BACKHOE THAT IS ALSO INSTALLED ON TRACTOR THAT IS EASY TO REMOVE. I ALSO HAVE TO GO WITH IT A 54 SNOW BLADE THAT IS HYDRAULIC C...

Well maintained Yard Machines 21 Hp Riding Mower Lawn Tractor pedal drive speed control. It has a fresh oil change, new oil filter, new blades 3, and new deck belt. Its ready to use. If you see this post its still for sale... only respond if youre ready to buy.

Craftsman 2-stage 42 snowblower with all controls to operate right from the drivers seat. Includes all mounting hardware, wheel weights, chains. Works great Asking $450 or best CASH offer might do some trading towards carry conceal or other bang the last picture is the riding mower the snow thrower fits which could also be available for the right price Reply with phone number<|endoftext|>Q:

How does Comma separated files work?...if the text has commas in it

I never understood this.

A:

Wikipdedia has the info you want

Fields with embedded commas must be enclosed within double-quote characters.

<|endoftext|>Intravenous digital subtraction angiography in the evaluation of potential renal donors.
Of 65 surgically removed donor kidneys intravenous digital subtraction angiography demonstrated accurately the number of renal arteries in 58 (89 per cent). All accessory vessels missed at digital subtraction angiography were small and their presence did not interfere with successful transplantation in those donated. Of 50 surgically removed donor kidneys examined with conventional aortography only before the routine use of intravenous digital subtraction angiography the number of renal arteries was demonstrated accurately in 46 (92 per cent). Intravenous digital subtraction angiography offers advantages over conventional aortography, including most importantly the routine performance on an outpatient basis, and decreased film cost and examination time. Although the accuracy of conventional aortography (92 per cent) in detecting the number of renal arteries is slightly greater than that for intravenous digital subtraction angiography (89 per cent), the advantages of the digital examination justify its use as the initial examination for the potential renal donor. Conventional aortography can be reserved for use in patients with equivocal or technically inadequate digital examinations.<|endoftext|>Merimnetria

Merimnetria is a genus of moths in the family Gelechiidae. It was first described by Lord Walsingham in 1907. All species are endemic to Hawaii.

Species
Subgenus Aristoteliodes Zimmerman, 1978
Merimnetria arcuata (Walsingham, 1907)
Merimnetria compsodelta (Meyrick, 1928)
Merimnetria elegantior (Walsingham, 1907)
Merimnetria epermeniella (Walsingham, 1907)
Merimnetria gigantea (Swezey, 1913)
Merimnetria gratula (Meyrick, 1928)
Merimnetria homoxyla (Meyrick, 1928)
Merimnetria ichthyochroa (Walsingham, 1907)
Merimnetria lanaiensis (Walsingham, 1907)
Merimnetria maculaticornis (Walsingham, 1907)
Merimnetria mendax (Walsingham, 1907)
Merimnetria multiformis (Meyrick, 1928)
Merimnetria nigriciliella (Walsingham, 1907)
Merimnetria notata (Walsingham, 1907)
Merimnetria thurifica (Meyrick, 1928)
Merimnetria xylospila (Meyrick, 1928)
Subgenus Merimnetria
Merimnetria flaviterminella Walsingham, 1907
Merimnetria straussiella (Swezey,