NEURON { SUFFIX sm NONSPECIFIC_CURRENT i USEION na WRITE ina USEION k WRITE ik } STATE { na_gates_m_q na_gates_h_q k_gates_n_q } BREAKPOINT { SOLVE dstate METHOD cnexp LOCAL g_na, g_k g_k = 0.036 * k_gates_n_q * k_gates_n_q * k_gates_n_q * k_gates_n_q ik = g_k * (v + 77) g_na = 0.12 * na_gates_h_q * na_gates_m_q * na_gates_m_q * na_gates_m_q ina = g_na * (v - 50) i = 0.0003 * (v + 54.387) } INITIAL { LOCAL na_gates_h_reverseRate_r, na_gates_h_forwardRate_r, na_gates_m_reverseRate_r, na_gates_m_forwardRate_x, na_gates_m_forwardRate_r LOCAL k_gates_n_reverseRate_r, k_gates_n_forwardRate_x, k_gates_n_forwardRate_r na_gates_h_forwardRate_r = 0.07000000029802322 * exp(-0.05 * (65 + v)) na_gates_h_reverseRate_r = 1/(1 + exp(-0.1 * (35 + v))) na_gates_m_reverseRate_r = 4 * exp(-0.05555555555555555 * (65 + v)) na_gates_m_forwardRate_x = 0.1 * (40 + v) na_gates_m_forwardRate_r = 1 if (na_gates_m_forwardRate_x != 0) { na_gates_m_forwardRate_r = na_gates_m_forwardRate_x / (1 - exp(-na_gates_m_forwardRate_x)) } na_gates_m_q = na_gates_m_forwardRate_r / (na_gates_m_forwardRate_r + na_gates_m_reverseRate_r) na_gates_h_q = na_gates_h_forwardRate_r / (na_gates_h_forwardRate_r + na_gates_h_reverseRate_r) k_gates_n_reverseRate_r = 0.125 * exp(-0.0125 * (65 + v)) k_gates_n_forwardRate_x = 0.1 * (55 + v) k_gates_n_forwardRate_r = 0.10000000149011612 if (k_gates_n_forwardRate_x != 0) { k_gates_n_forwardRate_r = 0.10000000149011612 * k_gates_n_forwardRate_x / (1 - exp(-k_gates_n_forwardRate_x)) } k_gates_n_q = k_gates_n_forwardRate_r / (k_gates_n_forwardRate_r + k_gates_n_reverseRate_r) } DERIVATIVE dstate { LOCAL na_gates_h_forwardRate_r, na_gates_h_reverseRate_r, na_gates_m_reverseRate_r, na_gates_m_forwardRate_x, na_gates_m_forwardRate_r LOCAL k_gates_n_reverseRate_r, k_gates_n_forwardRate_x, k_gates_n_forwardRate_r na_gates_h_forwardRate_r = 0.07000000029802322 * exp(-0.05 * (65 + v)) na_gates_h_reverseRate_r = 1/(1 + exp(-0.1 * (35 + v))) na_gates_m_reverseRate_r = 4 * exp(-0.05555555555555555 * (65 + v)) na_gates_m_forwardRate_x = 0.1 * (40 + v) na_gates_m_forwardRate_r = 1 if (na_gates_m_forwardRate_x != 0) { na_gates_m_forwardRate_r = na_gates_m_forwardRate_x / (1 - exp(-na_gates_m_forwardRate_x)) } k_gates_n_reverseRate_r = 0.125 * exp(-0.0125 * (65 + v)) k_gates_n_forwardRate_x = 0.1 * (55 + v) k_gates_n_forwardRate_r = 0.10000000149011612 if (k_gates_n_forwardRate_x != 0) { k_gates_n_forwardRate_r = 0.10000000149011612 * k_gates_n_forwardRate_x / (1 - exp(-k_gates_n_forwardRate_x)) } na_gates_m_q' = na_gates_m_forwardRate_r - na_gates_m_q*(na_gates_m_forwardRate_r + na_gates_m_reverseRate_r) na_gates_h_q' = na_gates_h_forwardRate_r - na_gates_h_q*(na_gates_h_forwardRate_r + na_gates_h_reverseRate_r) k_gates_n_q' = k_gates_n_forwardRate_r - k_gates_n_q *(k_gates_n_forwardRate_r + k_gates_n_reverseRate_r) }