{
  "consequences": [
    "chromosome_number_variation",
    "exon_loss_variant",
    "frameshift_variant",
    "rare_amino_acid_variant",
    "splice_acceptor_variant",
    "splice_donor_variant",
    "start_lost",
    "stop_gained",
    "stop_lost",
    "transcript_ablation",
    "3_prime_UTR_truncation",
    "5_prime_UTR_truncation",
    "conservative_inframe_deletion",
    "conservative_inframe_insertion",
    "disruptive_inframe_deletion",
    "disruptive_inframe_insertion",
    "missense_variant",
    "regulatory_region_ablation",
    "splice_region_variant",
    "TFBS_ablation",
    "5_prime_UTR_premature_start_codon_gain_variant",
    "initiator_codon_variant",
    "start_retained",
    "stop_retained_variant",
    "synonymous_variant",
    "3_prime_UTR_variant",
    "5_prime_UTR_variant",
    "coding_sequence_variant",
    "conserved_intergenic_variant",
    "conserved_intron_variant",
    "downstream_gene_variant",
    "exon_variant",
    "feature_elongation",
    "feature_truncation",
    "gene_variant",
    "intergenic_variant",
    "intron_variant",
    "mature_miRNA_variant",
    "miRNA",
    "NMD_transcript_variant",
    "non_coding_transcript_exon_variant",
    "non_coding_transcript_intron_variant",
    "regulatory_region_amplification",
    "regulatory_region_variant",
    "TF_binding_site_variant",
    "TFBS_amplification",
    "transcript_amplification",
    "transcript_variant",
    "upstream_gene_variant"
  ],
  "gnomad_exomes_enabled": true,
  "gnomad_genomes_enabled": true,
  "inhouse_enabled": true,
  "helixmtdb_enabled": true,
  "quality": {
    "sample": {
      "dp_het": 10,
      "dp_hom": 5,
      "gq": 10,
      "ab": 0.2,
      "ad": 3,
      "ad_max": null,
      "filter_active": "drop-variant"
    }
  },
  "genotype": {
    "sample": "het"
  },
  "selected_variants": null,
  "transcripts_coding": true,
  "transcripts_noncoding": true,
  "var_type_snv": true,
  "var_type_indel": true,
  "var_type_mnv": true,
  "max_exon_dist": 100,
  "gene_allowlist": null,
  "genomic_regions": null,
  "require_in_clinvar": false,
  "clinvar_include_benign": false,
  "clinvar_include_pathogenic": true,
  "clinvar_include_likely_benign": false,
  "clinvar_include_likely_pathogenic": true,
  "clinvar_include_uncertain_significance": false,
  "gnomad_exomes_frequency": 0.002,
  "gnomad_exomes_heterozygous": 20,
  "gnomad_exomes_homozygous": 0,
  "gnomad_exomes_hemizygous": null,
  "gnomad_genomes_frequency": 0.002,
  "gnomad_genomes_heterozygous": 4,
  "gnomad_genomes_homozygous": 0,
  "gnomad_genomes_hemizygous": null,
  "inhouse_carriers": 20,
  "inhouse_heterozygous": null,
  "inhouse_homozygous": null,
  "inhouse_hemizygous": null,
  "helixmtdb_frequency": 0.01,
  "helixmtdb_heterozygous": null,
  "helixmtdb_homozygous": null
}